Controlled/living radical polymerization of multi-vinyl monomer towards hyperbranched polymers for biomedical applications
|Title:||Controlled/living radical polymerization of multi-vinyl monomer towards hyperbranched polymers for biomedical applications||Authors:||Zhao, Tianyu||Advisor:||Wang, Wenxin||Permanent link:||http://hdl.handle.net/10197/6852||Date:||2015||Online since:||2015-08-27T10:23:52Z||Abstract:||This thesis describes a novel route for the preparation of hyperbranched polymers. The aim is to produce veritable hyperbranched polymers from commercially available multi-vinyl monomers via in situ deactivation-enhanced ATRP at high conversion without crosslinking. The strategy is to alter the growth manner of polymerization by controlling the kinetic chain length together with manipulating chain growth conditions to achieve facile syntheses of 3D structured multifunctional materials.Chapter 1 provides a general introduction to the controlled/living radical polymerization, basic concepts of hyperbranched polymers, their preparation methods and their applications in biomedical field.Chapter 2 focuses on the study of different ATRA reaction system, including normal ATRA, ARGET ATRA and in situ DE-ATRA, for a better kinetic control of the polymerization of multi-vinyl monomers.Chapter 3 covers the hyperbranched homopolymers prepared by in situ enhanced deactivation ATRP, illustrating the ‘vinyl oligomer combination’ strategy as a universal approach towards hyperbranched polymers.Chapter 4 focuses on the synthesis of hyperbranched poly(PEGDA) as an efficient photo-crosslinked hydrogel.Chapter 5 demonstrates the synthesis of degradable cationic hyperbranched copolymers as efficient gene transfection agent. Also the significance of branching on transfection is explored.Chapter 6 summarises all the research presented in this thesis. Moreover, some possible research routes for the investigation in the future are listed in this part.||Type of material:||Doctoral Thesis||Publisher:||University College Dublin. School of Medicine and Medical Science||Qualification Name:||Ph.D.||Copyright (published version):||2015 the author||Keywords:||ATRP; CRP; Gene delivery; Hydrogel; Multi-vinyl monomer; Vinyl oligomer combination||Other versions:||http://dissertations.umi.com/ucd:10038||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Medicine Theses|
Show full item record
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.