Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

Files in This Item:
File Description SizeFormat 
M_Mc_Gee_Targeting_the_Mitotic_Catastrophe_Signaling_Pathway_in_Cancer.pdf2.07 MBAdobe PDFDownload
Title: Targeting the Mitotic Catastrophe Signaling Pathway in Cancer
Authors: Mc Gee, Margaret M.
Permanent link: http://hdl.handle.net/10197/7228
Date: 2015
Abstract: Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a major gateway to tumour development. Furthermore, the activation of mitotic catastrophe offers significant therapeutic advantage which has been exploited in the action of conventional and targeted anticancer agents. Yet, despite its importance in tumour prevention and treatment, the molecular mechanism of mitotic catastrophe is not well understood. A better understanding of the signals that determine cell fate following failed or defective mitosis will reveal new opportunities to selectively target and enhance the programme for therapeutic benefit and reveal biomarkers to predict patient response. This review is focused on the molecular mechanism of mitotic catastrophe induction and signalling and highlights current strategies to exploit the process in cancer therapy.
Funding Details: Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: Hindawi Publishing Corporation
Copyright (published version): 2015 the Author
Keywords: Mitotic catastrophe;Cancer therapy
DOI: 10.1155/2015/146282
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

Show full item record

SCOPUSTM   
Citations 10

26
Last Week
1
Last month
checked on Jun 15, 2018

Download(s) 50

77
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.