Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

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Title: Targeting the Mitotic Catastrophe Signaling Pathway in Cancer
Authors: Mc Gee, Margaret M.
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Date: 2015
Online since: 2015-11-18T10:09:14Z
Abstract: Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a major gateway to tumour development. Furthermore, the activation of mitotic catastrophe offers significant therapeutic advantage which has been exploited in the action of conventional and targeted anticancer agents. Yet, despite its importance in tumour prevention and treatment, the molecular mechanism of mitotic catastrophe is not well understood. A better understanding of the signals that determine cell fate following failed or defective mitosis will reveal new opportunities to selectively target and enhance the programme for therapeutic benefit and reveal biomarkers to predict patient response. This review is focused on the molecular mechanism of mitotic catastrophe induction and signalling and highlights current strategies to exploit the process in cancer therapy.
Funding Details: Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: Hindawi Publishing Corporation
Journal: Mediators of Inflammation
Volume: 2015
Issue: 146282
Start page: 1
End page: 13
Copyright (published version): 2015 the Author
Keywords: Mitotic catastropheCancer therapy
DOI: 10.1155/2015/146282
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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