Development of nanotoxicology: implications for drug delivery and medical devices

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Title: Development of nanotoxicology: implications for drug delivery and medical devices
Authors: Bhattacharjee, S.Brayden, David James
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Date: Jul-2015
Online since: 2016-07-01T01:00:09Z
Abstract: Current nanotoxicology research suffers from suboptimal in vitro models, lack of in vitro–in vivo correlations, variability within in vitro protocols, deficits in both material purity and physicochemical characterization. Reliable nanomaterial toxicity and mechanistic insights are required for health and toxicity risk assessments. Much in vitro toxicological data is inconclusive in designating whether nanomaterials for drug delivery and medical device implants are truly safe. A critique is presented to analyze the interface between toxicology and nanopharmaceuticals. Deficiencies of existing practices in toxicology are reviewed and useful emerging techniques (e.g., lab-on-a-chip, tissue engineering, atomic force microscopy, high-content analysis) are highlighted. Cross-fertilization between disciplines will aid development of biocompatible delivery and implant platforms while improvements are being suggested for better translation of nanotoxicology.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of material: Journal Article
Publisher: Future Medicine
Journal: Nanomedicine
Volume: 10
Issue: 14
Start page: 2289
End page: 2305
Keywords: BiomaterialsHigh-content analysisLab-on-a-chipNanotoxicologyPredictive toxicology
DOI: 10.2217/nnm.15.69
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Veterinary Medicine Research Collection

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