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Development of nanotoxicology: implications for drug delivery and medical devices
Author(s)
Date Issued
2015-07
Date Available
2016-07-01T01:00:09Z
Abstract
Current nanotoxicology research suffers from suboptimal in vitro models, lack of in vitro–in vivo correlations, variability within in vitro protocols, deficits in both material purity and physicochemical characterization. Reliable nanomaterial toxicity and mechanistic insights are required for health and toxicity risk assessments. Much in vitro toxicological data is inconclusive in designating whether nanomaterials for drug delivery and medical device implants are truly safe. A critique is presented to analyze the interface between toxicology and nanopharmaceuticals. Deficiencies of existing practices in toxicology are reviewed and useful emerging techniques (e.g., lab-on-a-chip, tissue engineering, atomic force microscopy, high-content analysis) are highlighted. Cross-fertilization between disciplines will aid development of biocompatible delivery and implant platforms while improvements are being suggested for better translation of nanotoxicology.
Sponsorship
European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of Material
Journal Article
Publisher
Future Medicine
Journal
Nanomedicine
Volume
10
Issue
14
Start Page
2289
End Page
2305
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Nanomedicine_BhattacharjeeBrayden_ACCEPTED.docx
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5.51 MB
Format
Owning collection
Scopus© citations
12
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