Correlates of abnormal sensory discrimination in laryngeal dystonia

Files in This Item:
File Description SizeFormat 
Termsarasab_2015_TDT_laryngeal_dystonia.pdf1.17 MBAdobe PDFDownload
Title: Correlates of abnormal sensory discrimination in laryngeal dystonia
Authors: Termsarasab, Pichet
Ramdhani, Ritesh A.
Battistella, Giovanni
Hutchinson, Michael
et al.
Permanent link: http://hdl.handle.net/10197/7360
Date: Jan-2016
Abstract: Aberrant sensory processing plays a fundamental role in the pathophysiology of dystonia; however, its underpinning neural mechanisms in relation to dystonia phenotype and genotype remain unclear. We examined temporal and spatial discrimination thresholds in patients with isolated laryngeal form of dystonia (LD), who exhibited different clinical phenotypes (adductor vs. abductor forms) and potentially different genotypes (sporadic vs. familial forms). We correlated our behavioral findings with the brain gray matter volume and functional activity during resting and symptomatic speech production. We found that temporal but not spatial discrimination was significantly altered across all forms of LD, with higher frequency of abnormalities seen in familial than sporadic patients. Common neural correlates of abnormal temporal discrimination across all forms were found with structural and functional changes in the middle frontal and primary somatosensory cortices. In addition, patients with familial LD had greater cerebellar involvement in processing of altered temporal discrimination, whereas sporadic LD patients had greater recruitment of the putamen and sensorimotor cortex. Based on the clinical phenotype, adductor form-specific correlations between abnormal discrimination and brain changes were found in the frontal cortex, whereas abductor form-specific correlations were observed in the cerebellum and putamen. Our behavioral and neuroimaging findings outline the relationship of abnormal sensory discrimination with the phenotype and genotype of isolated LD, suggesting the presence of potentially divergent pathophysiological pathways underlying different manifestations of this disorder.
Funding Details: Health Research Board
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2015 the Authors
Keywords: Sensory processingEndophenotypeBrain imaging
DOI: 10.1016/j.nicl.2015.10.016
Language: en
Status of Item: Peer reviewed
Appears in Collections:Medicine Research Collection

Show full item record

SCOPUSTM   
Citations 20

13
Last Week
0
Last month
checked on Sep 17, 2018

Download(s) 50

18
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.