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Frequency-dependent modulation of dopamine release by nicotine and dopamine D1 ligands: an in vitro fast cyclic voltammetry study in rat striatum
Date Issued
2016-03
Date Available
2017-03-01T02:00:33Z
Abstract
Nicotine is a highly addictive drug and exerts this effect partially through the modulation of dopamine release and increasing extracellular dopamine in regions such as the brain reward systems. Nicotine acts in these regions on nicotinic acetylcholine receptors. The effect of nicotine on the frequency dependent modulation of dopamine release is well established and the purpose of this study was to investigate whether dopamine D1 receptor (D1R) ligands have an influence on this. Using fast cyclic voltammetry and rat corticostriatal slices, we show that D1R ligands are able to modulate the effect of nicotine on dopamine release. Nicotine (500nM) induced a decrease in dopamine efflux at low frequency (single pulse or 5 pulses at 10Hz) and an increase at high frequency (100Hz) electrical field stimulation. The D1R agonist SKF-38393, whilst having no effect on dopamine release on its own or on the effect of nicotine upon multiple pulse evoked dopamine release, did significantly prevent and reverse the effect of nicotine on single pulse dopamine release. Interestingly similar results were obtained with the D1R antagonist SCH-23390. In this study we have demonstrated that the modulation of dopamine release by nicotine can be altered by D1R ligands, but only when evoked by single pulse stimulation, and are likely working via cholinergic interneuron driven dopamine release.
Other Sponsorship
Abbott Healthcare Products
Type of Material
Journal Article
Publisher
Springer
Journal
Neurochemical Research
Volume
41
Issue
5
Start Page
945
End Page
950
Copyright (Published Version)
2016 Springer
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Owning collection
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7
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