Commercialized biomarkers: new horizons in prostate cancer diagnostics

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Title: Commercialized biomarkers: new horizons in prostate cancer diagnostics
Authors: Murphy, Lisa
Prencipe, Maria
Gallagher, William M.
Watson, R. William
Permanent link: http://hdl.handle.net/10197/7433
Date: 24-Feb-2015
Abstract: Limitations with current clinical tools available for diagnosis and prognosis of prostate cancer (PCa) have resulted in overdiagnosis and costly overtreatment, which is affecting the outcomes and quality of life of men. The biotech industry is investing significant resources into developing more specific biomarkers for PCa detection and patient stratification that would greatly advance the decision-making processes behind PCa management and treatment. In this review, we focus on those biomarkers that have been translated into commercial tests available to clinicians. Since these tests aim to fill specific gaps during the decision-making process of PCa management, we have grouped them based on the clinical question they claim to address, that is, improved PCa screening, false-negative biopsy dilemma, prognostic tests following a positive biopsy and tests predicting relapse/metastases after surgery. We evaluate each test with respect to its development, platform, clinical validation, biomatrix, regulatory approval status and cost.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: Expert Reviews
Copyright (published version): 2015 Expert Reviews
Keywords: Patented biomarkers;Commercialized prostate cancer tests;Prostate cancer screening;False-negative biopsy dilemma;Clinical utility
DOI: 10.1586/14737159.2015.1011622
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection
Medicine Research Collection

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