The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases

Files in This Item:
File Description SizeFormat 
O'Hurley_et_al,_Prostate_2014.pdf341.46 kBAdobe PDFDownload
Title: The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases
Authors: O'Hurley, Gillian
Prencipe, Maria
Lundon, Dara
O'Neill, Amanda
Boyce, Susie
Gallagher, William M.
Morrissey, Colm
Watson, R. William
et al.
Permanent link: http://hdl.handle.net/10197/7434
Date: Feb-2014
Abstract: Castration-resistant prostate cancer (CRPC) represents a challenge to treat with no effective treatment options available. We recently identified serum response factor (SRF) as a key transcription factor in an in vitro model of castration resistance where we showed that SRF inhibition resulted in reduced cellular proliferation. We also demonstrated an association between SRF protein expression and CRPC in a cohort of castrate-resistant transurethral resections of the prostate (TURPS). The mechanisms regulating the growth of CRPC bone and visceral metastases have not been explored in depth due to the paucity of patient-related material available for analysis. In this study, we aim to evaluate SRF protein expression in prostate cancer (PCa) metastases, which has not previously been reported.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Copyright (published version): 2013 Wiley Periodicals, Inc.
Keywords: Serum response factor;Prostate cancer metastases;Immunohistochemistry
DOI: 10.1002/pros.22752
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection
Medicine Research Collection

Show full item record

SCOPUSTM   
Citations 20

9
Last Week
1
Last month
checked on Jun 15, 2018

Download(s) 50

90
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.