The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases

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Title: The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases
Authors: O'Hurley, Gillian
Prencipe, Maria
Lundon, Dara
O'Neill, Amanda
Boyce, Susie
Gallagher, William M.
Morrissey, Colm
Watson, R. William
et al.
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Date: Feb-2014
Abstract: Castration-resistant prostate cancer (CRPC) represents a challenge to treat with no effective treatment options available. We recently identified serum response factor (SRF) as a key transcription factor in an in vitro model of castration resistance where we showed that SRF inhibition resulted in reduced cellular proliferation. We also demonstrated an association between SRF protein expression and CRPC in a cohort of castrate-resistant transurethral resections of the prostate (TURPS). The mechanisms regulating the growth of CRPC bone and visceral metastases have not been explored in depth due to the paucity of patient-related material available for analysis. In this study, we aim to evaluate SRF protein expression in prostate cancer (PCa) metastases, which has not previously been reported.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Copyright (published version): 2013 Wiley Periodicals, Inc.
Keywords: Serum response factorProstate cancer metastasesImmunohistochemistry
DOI: 10.1002/pros.22752
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection
Medicine Research Collection

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