Systems biology embedded target validation: improving efficacy in drug discovery
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|Title:||Systems biology embedded target validation: improving efficacy in drug discovery||Authors:||Vandamme, Drieke
Minke, Benedikt A.
Kholodenko, Boris N.
|Permanent link:||http://hdl.handle.net/10197/7555||Date:||Feb-2014||Online since:||2016-04-08T11:30:18Z||Abstract:||The pharmaceutical industry is faced with a range of challenges with the ever-escalating costs of drug development and a drying out of drug pipelines. By harnessing advances in -omics technologies and moving away from the standard, reductionist model of drug discovery, there is significant potential to reduce costs and improve efficacy. Embedding systems biology approaches in drug discovery, which seek to investigate underlying molecular mechanisms of potential drug targets in a network context, will reduce attrition rates by earlier target validation and the introduction of novel targets into the currently stagnant market. Systems biology approaches also have the potential to assist in the design of multidrug treatments and repositioning of existing drugs, while stratifying patients to give a greater personalization of medical treatment.||Funding Details:||European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
|Type of material:||Journal Article||Publisher:||Wiley||Journal:||Wiley Interdisciplinary Reviews: Systems Biology and Medicine||Volume:||6||Issue:||1||Start page:||1||End page:||11||Copyright (published version):||2013 Wiley Periodicals, Inc.||Keywords:||Drug discovery; Systems biology; Multidrug treatment; Personalized medicine||DOI:||10.1002/wsbm.1253||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Conway Institute Research Collection|
SBI Research Collection
Medicine Research Collection
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