Systems biology embedded target validation: improving efficacy in drug discovery

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Title: Systems biology embedded target validation: improving efficacy in drug discovery
Authors: Vandamme, Drieke
Minke, Benedikt A.
Fitzmaurice, William
Kholodenko, Boris N.
Kolch, Walter
Permanent link: http://hdl.handle.net/10197/7555
Date: Feb-2014
Abstract: The pharmaceutical industry is faced with a range of challenges with the ever-escalating costs of drug development and a drying out of drug pipelines. By harnessing advances in -omics technologies and moving away from the standard, reductionist model of drug discovery, there is significant potential to reduce costs and improve efficacy. Embedding systems biology approaches in drug discovery, which seek to investigate underlying molecular mechanisms of potential drug targets in a network context, will reduce attrition rates by earlier target validation and the introduction of novel targets into the currently stagnant market. Systems biology approaches also have the potential to assist in the design of multidrug treatments and repositioning of existing drugs, while stratifying patients to give a greater personalization of medical treatment.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Journal: Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume: 6
Issue: 1
Start page: 1
End page: 11
Copyright (published version): 2013 Wiley Periodicals, Inc.
Keywords: Drug discoverySystems biologyMultidrug treatmentPersonalized medicine
DOI: 10.1002/wsbm.1253
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection
Medicine Research Collection

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