Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathway

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Title: Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathway
Authors: Rowan, Simon C.
Keane, M. P.
Gaine, Seán
McLoughlin, Paul
Permanent link: http://hdl.handle.net/10197/7557
Date: Mar-2016
Online since: 2016-08-16T01:00:10Z
Abstract: Pulmonary hypertension is a well recognised complication of chronic hypoxic lung diseases, which are among the most common causes of death and disability worldwide. Development of pulmonary hypertension independently predicts reduced life expectancy. In chronic obstructive pulmonary disease, long-term oxygen therapy ameliorates pulmonary hypertension and greatly improves survival, although the correction of alveolar hypoxia and pulmonary hypertension is only partial. Advances in understanding of the regulation of vascular smooth muscle tone show that chronic vasoconstriction plays a more important part in the pathogenesis of hypoxic pulmonary hypertension than previously thought, and that structural vascular changes contribute less. Trials of existing vasodilators show that pulmonary hypertension can be ameliorated and systemic oxygen delivery improved in carefully selected patients, although systemic hypotensive effects limit the doses used. Vasoconstrictor pathways that are selective for the pulmonary circulation can be blocked to reduce hypoxic pulmonary hypertension without causing systemic hypotension, and thus provide potential targets for novel therapeutic strategies.
Funding Details: Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: Elsevier
Journal: The Lancet Respiratory Medicine
Volume: 4
Issue: 3
Start page: 225
End page: 236
Copyright (published version): 2016 Elsevier
Keywords: Pulmonary hypertensionVasoconstrictionSignalling pathways
DOI: 10.1016/S2213-2600(15)00517-2
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection

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