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Wettability gradient-induced alignment of peptide nanotubes as templates for biosensing applications
Date Issued
2016
Date Available
2017-04-01T01:00:14Z
Abstract
Self-assembled diphenylalanine (FF) peptide nanotubes (PNTs) have attracted significant attention due to their well-ordered supramolecular structure and wide range of functional capabilities that may enable potential nanobiotechnology applications. However, self-assembled PNTs are generally inhomogeneous at the macroscale, which has limited their potential use. Reproducibly controlling the assembly and alignment of PNTs is therefore critical to enable the widespread use of PNTs, e.g., in sensing applications. In this study, a surface patterning technique based on UV/ozone exposure through a mask is used to align PNTs. Exposed regions become hydrophilic, leading to directed spreading of the FF solution and alignment of the PNTs that improves as the difference in wettability between adjacent regions increases. Alignment was further found to depend on the concentration- and temperature-dependent diameter of the PNTs formed and the size of the hydrophilic area. Finally, aligned PNTs decorated with silver nanoparticles are used to sense an analyte molecule using surface enhanced Raman spectroscopy.
Sponsorship
European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Other Sponsorship
Ministry of Higher Education of Saudi Arabia under the King Abdullah Scholarship Program
Russian Scientific Foundation
CICECO–Aveiro Institute of Materials
Type of Material
Journal Article
Publisher
Royal Society of Chemistry
Journal
RSC Advances
Volume
6
Start Page
41809
End Page
41815
Copyright (Published Version)
2016 The Royal Society of Chemistry
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Peptide Alignment RSC Advances 20160510 Repository Version.pdf
Size
953.95 KB
Format
Owning collection
Scopus© citations
32
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