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  5. Novel placental ultrasound assessment: Potential role in pre-gestational diabetic pregnancy
 
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Novel placental ultrasound assessment: Potential role in pre-gestational diabetic pregnancy

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Author(s)
Moran, Mary 
Mulcahy, C. 
Daly, Leslie E. 
Zombori, Gergely 
Downey, P. 
McAuliffe, Fionnuala M. 
Uri
http://hdl.handle.net/10197/7662
Date Issued
August 2014
Date Available
02T11:29:09Z June 2016
Abstract
Objectives: Management of women with pre-gestational diabetes continues to be challenging for clinicians. This study aims to determine if 3D power Doppler (3DPD) analysis of placental volume and flow, and calculation of placental calcification using a novel software method, differ between pregnancies with type 1 or type 2 diabetes and normal controls, and if there is a relationship between these ultrasound placental parameters and clinical measures in diabetics. Methods: This was a prospective cohort study of 50 women with diabetes and 250 controls (12–40 weeks gestation). 3DPD ultrasound was used to evaluate placental volume, vascularisation index (VI), flow index (FI) and vascularisation-flow index (VFI). Placental calcification was calculated by computer analysis. Results in diabetics were compared with control values, and correlated with early pregnancy HbA1c, Doppler results and placental histology. Results: Placental calcification and volume increased with advancing gestation in pre-gestational diabetic placentae. Volume was also found to be significantly higher than in normal placentae. VI and VFI were significantly lower in diabetic pregnancies between 35 and 40 weeks gestation. A strong relationship was seen between a larger placental volume and both increasing umbilical artery pulsatility index and decreasing middle cerebral artery pulsatility index. FI was significantly lower in cases which had a booking HbA1c level ≥6.5%. Ultrasound assessed placental calcification was reduced with a histology finding of delayed villous maturation. No other correlation with placental histology was found. Conclusions: This study shows a potential role for 3D placental evaluation, and computer analysis of calcification, in monitoring pre-gestational diabetic pregnancies.
Type of Material
Journal Article
Publisher
Elsevier
Journal
Placenta
Volume
35
Issue
8
Start Page
639
End Page
644
Copyright (Published Version)
2014 Elsevier
Keywords
  • Pre-gestational diabe...

  • Novel ultrasound plac...

DOI
10.1016/j.placenta.2014.03.007
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Owning collection
Medicine Research Collection
Scopus© citations
17
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Feb 1, 2023
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