The Effects of Hypoxia and Inflammation on Synaptic Function in the CNS

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Title: The Effects of Hypoxia and Inflammation on Synaptic Function in the CNS
Authors: Mukandala, Gatambwa
Tynan, Ronan
Lanigan, Sinead
O'Connor, J. J.
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Date: 17-Feb-2016
Abstract: Normal brain function is highly dependent on oxygen and nutrient supply and when the demand for oxygen exceeds its supply, hypoxia is induced. Acute episodes of hypoxia may cause a depression in synaptic activity in many brain regions, whilst prolonged exposure to hypoxia leads to neuronal cell loss and death. Acute inadequate oxygen supply may cause anaerobic metabolism and increased respiration in an attempt to increase oxygen intake whilst chronic hypoxia may give rise to angiogenesis and erythropoiesis in order to promote oxygen delivery to peripheral tissues. The effects of hypoxia on neuronal tissue are exacerbated by the release of many inflammatory agents from glia and neuronal cells. Cytokines, such as TNF-α, and IL-1β are known to be released during the early stages of hypoxia, causing either local or systemic inflammation, which can result in cell death. Another growing body of evidence suggests that inflammation can result in neuroprotection, such as preconditioning to cerebral ischemia, causing ischemic tolerance. In the following review we discuss the effects of acute and chronic hypoxia and the release of pro-inflammatory cytokines on synaptic transmission and plasticity in the central nervous system. Specifically we discuss the effects of the pro-inflammatory agent TNF-α during a hypoxic event.
Funding Details: University College Dublin
Type of material: Journal Article
Publisher: MDPI
Journal: Brain Sciences
Volume: 6
Issue: 6
Start page: 1
End page: 14
Keywords: HIF-1αTNF-αAdenosineHippocampusHypoxiaLong-term potentiationProlyl hydroxylase inhibitor
DOI: 10.3390/brainsci6010006
Language: en
Status of Item: Peer reviewed 2016-06-27T12:39:53Z
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection

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