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Pharmacological Restoration of Visual Function in a Blind Zebrafish Mutant Following Histone Deacetylase Inhibitor (HDACi) Treatment
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| Title: | Pharmacological Restoration of Visual Function in a Blind Zebrafish Mutant Following Histone Deacetylase Inhibitor (HDACi) Treatment | Authors: | Kennedy, Breandán; Shine, Lisa; Heffernan, Theresa; Cagney, Gerard; Daly, Cara T. | Permanent link: | http://hdl.handle.net/10197/7784 | Date: | Jul-2016 | Online since: | 2016-07-25T12:22:28Z | Abstract: | Background: Controversially, histone deacetylase (HDAC) inhibitors are in clinical trial for the treatment of inherited retinal degenerations. Previous studies report that patients suffering from Retinitis Pigmentosa (RP) show improved visual field and acuity following treatment with the HDAC inhibitor valproic acid (VPA) (Clemson, Tzekov et al. 2011). However, other studies disagree with these findings (van Schooneveld, van den Born et al. 2011) and (Bhalla, Joshi et al. 2013). Thus, we sought to determine if treatment with HDACi rescued visual function and retinal morphology in a blind zebrafish dying-on-edge (dye) mutant identified from a forward genetics screen. | Type of material: | Journal Article | Publisher: | British Pharmacological Society | Journal: | pA2 Online | Volume: | 13 | Issue: | 3 | Start page: | 222P | Keywords: | Visual function; Retinal degneration; Zebrafish model | Other versions: | http://www.pa2online.org/abstracts/vol13issue3abst222p.pdf | Language: | en | Status of Item: | Not peer reviewed | This item is made available under a Creative Commons License: | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ |
| Appears in Collections: | Conway Institute Research Collection Biomolecular and Biomedical Science Research Collection |
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