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Pharmacological Restoration of Visual Function in a Blind Zebrafish Mutant Following Histone Deacetylase Inhibitor (HDACi) Treatment
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| Title: | Pharmacological Restoration of Visual Function in a Blind Zebrafish Mutant Following Histone Deacetylase Inhibitor (HDACi) Treatment | Authors: | Kennedy, Breandán Shine, Lisa Heffernan, Theresa Cagney, Gerard Daly, Cara T. |
Permanent link: | http://hdl.handle.net/10197/7784 | Date: | Jul-2016 | Abstract: | Background: Controversially, histone deacetylase (HDAC) inhibitors are in clinical trial for the treatment of inherited retinal degenerations. Previous studies report that patients suffering from Retinitis Pigmentosa (RP) show improved visual field and acuity following treatment with the HDAC inhibitor valproic acid (VPA) (Clemson, Tzekov et al. 2011). However, other studies disagree with these findings (van Schooneveld, van den Born et al. 2011) and (Bhalla, Joshi et al. 2013). Thus, we sought to determine if treatment with HDACi rescued visual function and retinal morphology in a blind zebrafish dying-on-edge (dye) mutant identified from a forward genetics screen. | Type of material: | Journal Article | Publisher: | British Pharmacological Society | Keywords: | Visual function;Retinal degneration;Zebrafish model | Language: | en | Status of Item: | Not peer reviewed |
| Appears in Collections: | Conway Institute Research Collection Biomolecular and Biomedical Science Research Collection |
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