Pharmacological Restoration of Visual Function in a Blind Zebrafish Mutant Following Histone Deacetylase Inhibitor (HDACi) Treatment

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Title: Pharmacological Restoration of Visual Function in a Blind Zebrafish Mutant Following Histone Deacetylase Inhibitor (HDACi) Treatment
Authors: Kennedy, Breandán
Shine, Lisa
Heffernan, Theresa
Cagney, Gerard
Daly, Cara T.
Permanent link: http://hdl.handle.net/10197/7784
Date: Jul-2016
Abstract: Background: Controversially, histone deacetylase (HDAC) inhibitors are in clinical trial for the treatment of inherited retinal degenerations. Previous studies report that patients suffering from Retinitis Pigmentosa (RP) show improved visual field and acuity following treatment with the HDAC inhibitor valproic acid (VPA) (Clemson, Tzekov et al. 2011). However, other studies disagree with these findings (van Schooneveld, van den Born et al. 2011) and (Bhalla, Joshi et al. 2013). Thus, we sought to determine if treatment with HDACi rescued visual function and retinal morphology in a blind zebrafish dying-on-edge (dye) mutant identified from a forward genetics screen.
Type of material: Journal Article
Publisher: British Pharmacological Society
Keywords: Visual function;Retinal degneration;Zebrafish model
Language: en
Status of Item: Not peer reviewed
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection

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