Intestinal permeation enhancers for oral peptide delivery

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Title: Intestinal permeation enhancers for oral peptide delivery
Authors: Maher, Sam
Mrsny, Randall J.
Brayden, David James
Permanent link: http://hdl.handle.net/10197/7800
Date: 15-Nov-2016
Abstract: Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action of over 250 PEs that have been tested in intestinal delivery models. In depth analysis of pre-clinical data is presented for PEs as components of proprietary delivery systems that have progressed to clinical trials. Given the importance of co-presentation of sufficiently high concentrations of PE and peptide at the small intestinal epithelium, there is an emphasis on studies where PEs have been formulated with poorly permeable molecules in solid dosage forms and lipoidal dispersions.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2016 Elsevier
Keywords: Oral peptide delivery;Intestinal permeation enhancers;Paracellular transport;Transcellular;Solid dose formulation;Surfactants;Emulsions
DOI: 10.1016/j.addr.2016.06.005
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Veterinary Medicine Research Collection

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