Intestinal permeation enhancers for oral peptide delivery
|Title:||Intestinal permeation enhancers for oral peptide delivery||Authors:||Maher, Sam; Mrsny, Randall J.; Brayden, David James||Permanent link:||http://hdl.handle.net/10197/7800||Date:||15-Nov-2016||Online since:||2017-06-16T01:00:14Z||Abstract:||Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action of over 250 PEs that have been tested in intestinal delivery models. In depth analysis of pre-clinical data is presented for PEs as components of proprietary delivery systems that have progressed to clinical trials. Given the importance of co-presentation of sufficiently high concentrations of PE and peptide at the small intestinal epithelium, there is an emphasis on studies where PEs have been formulated with poorly permeable molecules in solid dosage forms and lipoidal dispersions.||Funding Details:||European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
|Funding Details:||RCSI School of Pharmacy||Type of material:||Journal Article||Publisher:||Elsevier||Journal:||Advanced Drug Delivery Reviews||Issue:||Part B||Start page:||277||End page:||319||Copyright (published version):||2016 Elsevier||Keywords:||Oral peptide delivery; Intestinal permeation enhancers; Paracellular transport; Transcellular; Solid dose formulation; Surfactants; Emulsions||DOI:||10.1016/j.addr.2016.06.005||Language:||en||Status of Item:||Peer reviewed||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by-nc-nd/3.0/ie/|
|Appears in Collections:||Conway Institute Research Collection|
Veterinary Medicine Research Collection
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