Towards Biofunctional Microneedles for Stimulus Responsive Drug Delivery

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Title: Towards Biofunctional Microneedles for Stimulus Responsive Drug Delivery
Authors: Cahill, Ellen Mary
O'Cearbhaill, Eoin D.
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Date: 2015
Online since: 2016-08-23T12:52:28Z
Abstract: Microneedles have recently been adopted for use as a painless and safe method of transdermal therapeutic delivery through physically permeating the stratum corneum. While microneedles create pathways to introduce drugs, they can also act as conduits for biosignal sensing. Here, we explore the development of microneedles as both biosensing and drug delivery platforms. Microneedle sensors are being developed for continuous monitoring of biopotentials and bioanalytes through the use of conductive and electrochemically reactive biomaterials. The range of therapeutics being delivered through microneedle devices has diversified, while novel bioabsorbable microneedles are undergoing first-in-human clinical studies. We foresee that future microneedle platform development will focus on the incorporation of biofunctional materials, designed to deliver therapeutics in a stimulus responsive fashion. Biofunctional microneedle patches will require improved methods of attaching to and conforming to epithelial tissues in dynamic environments for longer periods of time and thus present an assortment of new design challenges. Through the evolution of biomaterial development and microneedle design, biofunctional microneedles are proposed as a next generation of stimulus responsive drug delivery systems.
Type of material: Journal Article
Publisher: American Chemical Society
Journal: Bioconjugate chemistry
Volume: 26
Issue: 7
Start page: 1289
End page: 1296
Copyright (published version): 2015 American Chemical Society
Keywords: Biofunctional biomaterialsMedical devices
DOI: 10.1021/acs.bioconjchem.5b00211
Language: en
Status of Item: Peer reviewed
Appears in Collections:Mechanical & Materials Engineering Research Collection
Conway Institute Research Collection

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