Dynamic mechanical properties of murine brain tissue using micro-indentation

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Title: Dynamic mechanical properties of murine brain tissue using micro-indentation
Authors: MacManus, D. B.
Pierrat, B.
Murphy, Jeremiah G.
Gilchrist, M. D.
Permanent link: http://hdl.handle.net/10197/7878
Date: 18-Sep-2015
Abstract: Significant advances have been made in recent decades to determine the macro-scale properties of brain tissue in compression, tension, shear and indentation. There has also been significant work done at the nanoscale using the AFM method to characterise the properties of individual neurons. However, there has been little published work on the micro-scale properties of brain tissue using an appropriate indentation methodology to characterise regional differences at dynamic strain rates. This paper presents a novel micro-indentation device that has been developed and used to measure the dynamic mechanical properties of brain tissue. The device is capable of applying up to 30/s strain rates with a maximum indentation area of 1500μm^2. Indentation tests were carried out to determine the shear modulus of the cerebellum (3.59±1.27 kPa) and cortex (7.05±3.92 kPa) of murine brain tissue at 30/s up to 14% strain. Numerical simulations were carried out to verify the experimentally measured force-displacement results.
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2015 Elsevier
Keywords: Traumatic Brain Injury (TBI)CortexCerebellumSneddonFinite element analysis
DOI: 10.1016/j.jbiomech.2015.06.028
Language: en
Status of Item: Peer reviewed
Appears in Collections:Mechanical & Materials Engineering Research Collection

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