Dynamic mechanical properties of murine brain tissue using micro-indentation

DC FieldValueLanguage
dc.contributor.authorMacManus, D. B.-
dc.contributor.authorPierrat, B.-
dc.contributor.authorMurphy, Jeremiah G.-
dc.contributor.authorGilchrist, M. D.-
dc.date.accessioned2016-09-06T12:15:05Z-
dc.date.available2016-09-18T01:00:22Z-
dc.date.copyright2015 Elsevieren
dc.date.issued2015-09-18-
dc.identifier.citationJournal of Biomechanicsen
dc.identifier.urihttp://hdl.handle.net/10197/7878-
dc.description.abstractSignificant advances have been made in recent decades to determine the macro-scale properties of brain tissue in compression, tension, shear and indentation. There has also been significant work done at the nanoscale using the AFM method to characterise the properties of individual neurons. However, there has been little published work on the micro-scale properties of brain tissue using an appropriate indentation methodology to characterise regional differences at dynamic strain rates. This paper presents a novel micro-indentation device that has been developed and used to measure the dynamic mechanical properties of brain tissue. The device is capable of applying up to 30/s strain rates with a maximum indentation area of 1500μm^2. Indentation tests were carried out to determine the shear modulus of the cerebellum (3.59±1.27 kPa) and cortex (7.05±3.92 kPa) of murine brain tissue at 30/s up to 14% strain. Numerical simulations were carried out to verify the experimentally measured force-displacement results.en
dc.description.sponsorshipScience Foundation Irelanden
dc.language.isoenen
dc.publisherElsevieren
dc.rightsThis is the author’s version of a work that was accepted for publication in Journal of Biomechanics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Biomechanics (VOL 48, ISSUE 12, (2015)) DOI: 10.1016/j.jbiomech.2015.06.028.en
dc.subjectTraumatic Brain Injury (TBI)en
dc.subjectCortexen
dc.subjectCerebellumen
dc.subjectSneddonen
dc.subjectFinite element analysisen
dc.titleDynamic mechanical properties of murine brain tissue using micro-indentationen
dc.typeJournal Articleen
dc.internal.authorcontactothermichael.gilchrist@ucd.ie-
dc.statusPeer revieweden
dc.identifier.volume48en
dc.identifier.issue12en
dc.identifier.startpage3213en
dc.identifier.endpage3218en
dc.identifier.doi10.1016/j.jbiomech.2015.06.028-
dc.neeo.contributorMacManus|D. B.|aut|-
dc.neeo.contributorPierrat|B.|aut|-
dc.neeo.contributorMurphy|Jeremiah G.|aut|-
dc.neeo.contributorGilchrist|M. D.|aut|-
dc.internal.rmsid543423888-
dc.date.updated2016-08-24T09:43:40Z-
item.grantfulltextopen-
item.fulltextWith Fulltext-
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