Options
Dynamic mechanical properties of murine brain tissue using micro-indentation
Date Issued
2015-09-18
Date Available
2016-09-18T01:00:22Z
Abstract
Significant advances have been made in recent decades to determine the macro-scale properties of brain tissue in compression, tension, shear and indentation. There has also been significant work done at the nanoscale using the AFM method to characterise the properties of individual neurons. However, there has been little published work on the micro-scale properties of brain tissue using an appropriate indentation methodology to characterise regional differences at dynamic strain rates. This paper presents a novel micro-indentation device that has been developed and used to measure the dynamic mechanical properties of brain tissue. The device is capable of applying up to 30/s strain rates with a maximum indentation area of 1500μm^2. Indentation tests were carried out to determine the shear modulus of the cerebellum (3.59±1.27 kPa) and cortex (7.05±3.92 kPa) of murine brain tissue at 30/s up to 14% strain. Numerical simulations were carried out to verify the experimentally measured force-displacement results.
Sponsorship
Science Foundation Ireland
Type of Material
Journal Article
Publisher
Elsevier
Journal
Journal of Biomechanics
Volume
48
Issue
12
Start Page
3213
End Page
3218
Copyright (Published Version)
2015 Elsevier
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
File(s)
Owning collection
Scopus© citations
33
Acquisition Date
Apr 17, 2024
Apr 17, 2024
Views
1600
Acquisition Date
Apr 17, 2024
Apr 17, 2024
Downloads
611
Last Week
4
4
Last Month
18
18
Acquisition Date
Apr 17, 2024
Apr 17, 2024