Elevated plasma CXCL12a is associated with a poorer prognosis in pulmonary arterial hypertension

Files in This Item:
File Description SizeFormat 
Elevated_plasma_CXCL12_is_associated_wiht_a_poorer_prognosis_in_PAH.pdf1.24 MBAdobe PDFDownload
Title: Elevated plasma CXCL12a is associated with a poorer prognosis in pulmonary arterial hypertension
Authors: McCullagh, Brian N.
Costello, Christine M.
Li, Lili
O'Connell, Caroline
Codd, Mary
McLoughlin, Paul
et al.
Permanent link: http://hdl.handle.net/10197/8033
Date: 9-Apr-2015
Abstract: Recent work in preclinical models suggests that signalling via the pro-angiogenic and pro-inflammatory cytokine, CXCL12 (SDF-1), plays an important pathogenic role in pulmonary hypertension (PH). The objective of this study was to establish whether circulating concentrations of CXCL12a were elevated in patients with PAH and related to mortality. Plasma samples were collected from patients with idiopathic pulmonary arterial hypertension (IPAH) and PAH associated with connective tissue diseases (CTD-PAH) attending two pulmonary hypertension referral centres (n = 95) and from age and gender matched healthy controls (n = 44). Patients were subsequently monitored throughout a period of five years. CXCL12a concentrations were elevated in PAH groups compared to controls (P<0.05) and receiver-operating-characteristic analysis showed that plasma CXCL12a concentrations discriminated patients from healthy controls (AUC 0.80, 95% confidence interval 0.73-0.88). Kaplan Meier analysis indicated that elevated plasma CXCL12a concentration was associated with reduced survival (P<0.01). Multivariate Cox proportional hazards model showed that elevated CXCL12a independently predicted (P<0.05) earlier death in PAH with a hazard ratio (95% confidence interval) of 2.25 (1.01-5.00). In the largest subset by WHO functional class (Class 3, 65% of patients) elevated CXCL12a independently predicted (P<0.05) earlier death, hazard ratio 2.27 (1.05-4.89). Our data show that elevated concentrations of circulating CXCL12a in PAH predicted poorer survival. Furthermore, elevated circulating CXCL12a was an independent risk factor for death that could potentially be included in a prognostic model and guide therapy.
Type of material: Journal Article
Publisher: Public Library of Science
Copyright (published version): 2015 the Authors
Keywords: Pulmonary hypertensionBlood plasmaPulmonary arteriesBlood pressureConnective tissue diseasesEndothelial cellsEthnic epidemiology
DOI: 10.1371/journal.pone.0123709
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection
Public Health, Physiotherapy and Sports Science Research Collection

Show full item record

SCOPUSTM   
Citations 50

1
Last Week
0
Last month
checked on Aug 17, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.