Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer

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Title: Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
Authors: Burke, Lorraine
Butler, Clare T.
Murphy, Adrian
Moran, Bruce
Gallagher, William M.
O'Sullivan, Jacintha
Kennedy, Breandán
Permanent link: http://hdl.handle.net/10197/8068
Date: 21-Sep-2016
Abstract: Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance. Cysteinyl leukotriene (CysLT) signaling regulates intestinal homeostasis with mounting evidence suggesting that CysLT signaling also plays a role in the pathogenesis of colorectal cancer. Therefore, CysLT signaling represents a novel target for this malignancy. This review evaluates reported links between CysLT signaling and established hallmarks of cancer in addition to its pharmacological potential as a new therapeutic target.Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance. Cysteinyl leukotriene (CysLT) signaling regulates intestinal homeostasis with mounting evidence suggesting that CysLT signaling also plays a role in the pathogenesis of colorectal cancer. Therefore CysLT signaling represents a novel target for this malignancy. This review evaluates reported links between CysLT signaling and established hallmarks of cancer in addition to its pharmacological potential as a new therapeutic target.
Type of material: Journal Article
Publisher: Frontiers Media
Journal: Frontiers in Cell and Developmental Biology
Volume: 4
Copyright (published version): 2016 the Authors
Keywords: Cysteinyl leukotrieneEicosanoidColorectal canceTumorigenesisHallmarks of cancerCysteinyl leukotriene receptor antagonist
DOI: 10.3389/fcell.2016.00103
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection

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