Hypoxic pulmonary hypertension: the paradigm is changing
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|Title:||Hypoxic pulmonary hypertension: the paradigm is changing||Authors:||Rowan, Simon C.
|Permanent link:||http://hdl.handle.net/10197/8196||Date:||1-Jun-2014||Abstract:||We began in the early 2000s to explore the hypothesis that vasoconstrictor mechanisms, selectively altered in the lung, were significant contributors to the increase in pulmonary vascular resistance in pulmonary hypertension. We found that in the normal rat pulmonary circulation the RhoA-ROCK pathway is a greater contributor to vasoconstriction than it is in systemic vessels, demonstrating an important phenotypic difference in the regulation of vascular tone in the two circulations.||Funding Details:||Health Research Board
Science Foundation Ireland
|Type of material:||Journal Article||Publisher:||Wiley||Keywords:||Hypoxia;Altitude sickness;RhoA-ROCK pathway||DOI:||10.1113/expphysiol.2014.078485||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Conway Institute Research Collection|
Medicine Research Collection
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