Hypoxic pulmonary hypertension: the paradigm is changing

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Title: Hypoxic pulmonary hypertension: the paradigm is changing
Authors: Rowan, Simon C.
McLoughlin, Paul
Permanent link: http://hdl.handle.net/10197/8196
Date: 1-Jun-2014
Abstract: We began in the early 2000s to explore the hypothesis that vasoconstrictor mechanisms, selectively altered in the lung, were significant contributors to the increase in pulmonary vascular resistance in pulmonary hypertension. We found that in the normal rat pulmonary circulation the RhoA-ROCK pathway is a greater contributor to vasoconstriction than it is in systemic vessels, demonstrating an important phenotypic difference in the regulation of vascular tone in the two circulations.
Funding Details: Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Journal: Experimental Physiology
Volume: 99
Issue: 6
Start page: 837
End page: 838
Keywords: HypoxiaAltitude sicknessRhoA-ROCK pathway
DOI: 10.1113/expphysiol.2014.078485
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection

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