Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis

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Title: Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis
Authors: Stephens, Niamh
Rawlings, Bernard
Caffrey, Patrick
Permanent link: http://hdl.handle.net/10197/8288
Date: 22-May-2013
Abstract: Actinoplanes caeruleus produces 67-121C, a heptaene macrolide modified with a D-mannosyl-D-mycosaminyl disaccharide. Draft genome sequencing revealed genes encoding mycosaminyltransferase, mycosamine synthase, a cytochrome P450 that modifies the macrolactone core, and the extending mannosyltransferase. Only the mycosamine synthase and P450 were active in the biosynthesis of amphotericins in Streptomyces nodosus, the amphotericin producer.
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: Taylor and Francis
Keywords: Polyene macrolide biosynthesis;Extending glycosyltransferase
DOI: 10.1271/bbb.120961
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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