Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis

Files in This Item:
File Description SizeFormat 
BBB_paper_accepted_manuscript_2013.pdf310.58 kBAdobe PDFDownload
Title: Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis
Authors: Stephens, Niamh
Rawlings, Bernard
Caffrey, Patrick
Permanent link:
Date: 22-May-2013
Abstract: Actinoplanes caeruleus produces 67-121C, a heptaene macrolide modified with a D-mannosyl-D-mycosaminyl disaccharide. Draft genome sequencing revealed genes encoding mycosaminyltransferase, mycosamine synthase, a cytochrome P450 that modifies the macrolactone core, and the extending mannosyltransferase. Only the mycosamine synthase and P450 were active in the biosynthesis of amphotericins in Streptomyces nodosus, the amphotericin producer.
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: Taylor and Francis
Keywords: Polyene macrolide biosynthesis;Extending glycosyltransferase
DOI: 10.1271/bbb.120961
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

Show full item record

Citations 20

Last Week
Last month
checked on Jun 23, 2018

Download(s) 50

checked on May 25, 2018

Google ScholarTM



This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.