Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis
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|Title:||Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis||Authors:||Stephens, Niamh
|Permanent link:||http://hdl.handle.net/10197/8288||Date:||22-May-2013||Abstract:||Actinoplanes caeruleus produces 67-121C, a heptaene macrolide modified with a D-mannosyl-D-mycosaminyl disaccharide. Draft genome sequencing revealed genes encoding mycosaminyltransferase, mycosamine synthase, a cytochrome P450 that modifies the macrolactone core, and the extending mannosyltransferase. Only the mycosamine synthase and P450 were active in the biosynthesis of amphotericins in Streptomyces nodosus, the amphotericin producer.||Funding Details:||Science Foundation Ireland||Type of material:||Journal Article||Publisher:||Taylor and Francis||Keywords:||Polyene macrolide biosynthesis;Extending glycosyltransferase||DOI:||10.1271/bbb.120961||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Biomolecular and Biomedical Science Research Collection|
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