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Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis
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| File | Description | Size | Format | |
|---|---|---|---|---|
| BBB_paper_accepted_manuscript_2013.pdf | 310.58 kB | Adobe PDF | Download |
| Title: | Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis | Authors: | Stephens, Niamh Rawlings, Bernard Caffrey, Patrick |
Permanent link: | http://hdl.handle.net/10197/8288 | Date: | 22-May-2013 | Abstract: | Actinoplanes caeruleus produces 67-121C, a heptaene macrolide modified with a D-mannosyl-D-mycosaminyl disaccharide. Draft genome sequencing revealed genes encoding mycosaminyltransferase, mycosamine synthase, a cytochrome P450 that modifies the macrolactone core, and the extending mannosyltransferase. Only the mycosamine synthase and P450 were active in the biosynthesis of amphotericins in Streptomyces nodosus, the amphotericin producer. | Funding Details: | Science Foundation Ireland | Type of material: | Journal Article | Publisher: | Taylor and Francis | Journal: | Bioscience Biotechnology and Biochemistry | Volume: | 77 | Issue: | 4 | Start page: | 880 | End page: | 883 | Keywords: | Polyene macrolide biosynthesis; Extending glycosyltransferase | DOI: | 10.1271/bbb.120961 | Language: | en | Status of Item: | Peer reviewed |
| Appears in Collections: | Biomolecular and Biomedical Science Research Collection |
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