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  5. Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis
 
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Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis

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Alternative Title
Enzymes Catalyzing Late Steps in 67-121C Biosynthesis
Author(s)
Stephens, Niamh 
Rawlings, Bernard 
Caffrey, Patrick 
Uri
http://hdl.handle.net/10197/8288
Date Issued
22 May 2013
Date Available
20T10:51:09Z January 2017
Abstract
Actinoplanes caeruleus produces 67-121C, a heptaene macrolide modified with a D-mannosyl-D-mycosaminyl disaccharide. Draft genome sequencing revealed genes encoding mycosaminyltransferase, mycosamine synthase, a cytochrome P450 that modifies the macrolactone core, and the extending mannosyltransferase. Only the mycosamine synthase and P450 were active in the biosynthesis of amphotericins in Streptomyces nodosus, the amphotericin producer.
Sponsorship
Science Foundation Ireland
Type of Material
Journal Article
Publisher
Taylor and Francis
Journal
Bioscience Biotechnology and Biochemistry
Volume
77
Issue
4
Start Page
880
End Page
883
Keywords
  • Polyene macrolide bio...

  • Extending glycosyltra...

DOI
10.1271/bbb.120961
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Owning collection
Biomolecular and Biomedical Science Research Collection
Scopus© citations
12
Acquisition Date
Jan 29, 2023
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1229
Acquisition Date
Jan 30, 2023
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Acquisition Date
Jan 30, 2023
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