On the personalised modelling of cancer signalling

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Title: On the personalised modelling of cancer signalling
Authors: Fey, Dirk
Kuehn, Axel
Kholodenko, Boris N.
Permanent link: http://hdl.handle.net/10197/8317
Date: 12-Oct-2016
Abstract: Dynamic modelling has long been used to understand fundamental principles of cell signalling and its dysregulation in cancer. More recently these models have also been used to understand the individual risks of cancer patients, and predict their survival probabilities. However, the current methodologies for integrating tumour data and generating patient-specific simulations suffer from the lack of general applicability; they only work for cell signalling models in which only posttranslational protein modifications are considered, so that the total protein concentrations are conserved. Here, we present novel, generally applicable method. The method is based on a simple theoretical framework for modelling gene-regulation, and the indirect estimation of patient-specific parameters from tumour data. Because our method does not require time-invariance of the total-protein concentrations, it can be applied to models of any nature, including the many cancer signalling models involving gene-regulation.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Type of material: Journal Article
Publisher: Elsevier
Journal: IFAC-PapersOnLine
Volume: 49
Issue: 26
Start page: 312
End page: 317
Copyright (published version): 2016 IFAC (International Federation of Automatic Control)
Keywords: Systems biologyOrdinary differential equationsParameter estimation
DOI: 10.1016/j.ifacol.2016.12.145
Language: en
Status of Item: Peer reviewed
Conference Details: 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE 2016), Magdeburg, Germany, 9-12 October 2016
Appears in Collections:SBI Research Collection
Medicine Research Collection

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