Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4me study

DC FieldValueLanguage
dc.contributor.authorKirwan, Laura
dc.contributor.authorWalsh, Marianne C.
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorO'Donovan, Clare
dc.contributor.authorWoolhead, Clara
dc.contributor.authorForster, Hannah
dc.contributor.authorGibney, Michael J.
dc.contributor.authorGibney, Eileen R.
dc.contributor.authorBrennan, Lorraine
dc.contributor.authoret al.
dc.date.accessioned2017-02-06T12:51:33Z
dc.date.available2017-02-06T12:51:33Z
dc.date.copyright2017 the Authorsen
dc.date.issued2016-12
dc.identifier.citationBritish Journal of Nutritionen
dc.identifier.urihttp://hdl.handle.net/10197/8319
dc.description.abstractIndividual response to dietary interventions can be highly variable. The phenotypic characteristics of those who will respond positively to personalised dietary advice are largely unknown. The objective of this study was to compare the phenotypic profiles of differential responders to personalised dietary intervention, with a focus on total circulating cholesterol. Subjects from the Food4Me multi-centre study were classified as responders or non-responders to dietary advice based on the change in cholesterol level from baseline to month 6, with lower and upper quartiles defined as the responder and non-responder groups, respectively. There were no significant differences between the demographic and anthropometric profiles of the groups. Furthermore, with the exception of alcohol, there was no significant difference in reported dietary intake, at baseline. However, there were marked differences in baseline fatty acid profiles. The responder group had significantly higher levels of stearic acid (18:0, p=0.034) and lower levels of palmitic acid (16:0, p=0.009). Total monounsaturated fatty acids (p=0.016) and total polyunsaturated fatty acids (p=0.008) also differed between the groups. In a stepwise logistic regression model, age, baseline total cholesterol, glucose, five fatty acids and alcohol intake were selected as factors that successfully discriminated responders from non-responders, with sensitivity of 82% and specificity of 83%. The successful delivery of personalised dietary advice may depend on our ability to identify phenotypes that are responsive. The results demonstrate the potential use of metabolic profiles in identifying response to an intervention and could play an important role in the development of precision nutrition.  en
dc.description.sponsorshipEuropean Commission - Seventh Framework Programme (FP7)en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.rightsThis article has been accepted for publication and will appear in a revised form, subsequent to peer review and/or editorial input by Cambridge University Press, in British Journal of Nutrition.en
dc.subjectPersonalised nutritionen
dc.subjectCholesterolen
dc.subjectRespondersen
dc.subjectPhenotypeen
dc.subjectFatty acid profileen
dc.titlePhenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4me studyen
dc.typeJournal Articleen
dc.internal.authorcontactotherlorraine.brennan@ucd.ie
dc.statusPeer revieweden
dc.identifier.volume116en
dc.identifier.issue12en
dc.identifier.startpage2011en
dc.identifier.endpage2019en
dc.identifier.doi10.1017/S0007114516004256-
dc.neeo.contributorKirwan|Laura|aut|-
dc.neeo.contributorWalsh|Marianne C.|aut|-
dc.neeo.contributorCelis-Morales|Carlos|aut|-
dc.neeo.contributorO'Donovan|Clare|aut|-
dc.neeo.contributorWoolhead|Clara|aut|-
dc.neeo.contributorForster|Hannah|aut|-
dc.neeo.contributorGibney|Michael J.|aut|-
dc.neeo.contributorGibney|Eileen R.|aut|-
dc.neeo.contributorBrennan|Lorraine|aut|-
dc.neeo.contributoret al.||aut|-
dc.internal.rmsid700055395
dc.date.updated2017-01-17T15:29:30Z
item.grantfulltextopen-
item.fulltextWith Fulltext-
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