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Quantifying nanoscale biochemical heterogeneity in human epithelial cancer cells using combined AFM and PTIR absorption nanoimaging
Date Issued
2015-01
Date Available
2017-02-16T12:56:40Z
Abstract
Subcellular chemical heterogeneity plays a key role in cell organization and function. However the biomechanics underlying the structure-function relationship is governed by cell substructures which are poorly resolved using conventional chemical imaging methods. To date, advances in sub-diffraction limited infrared (IR) nanoscopy have permitted intracellular chemical mapping. In this work we report how image analysis applied to a combination of IR absorption nanoimaging and topographic data permits quantification of chemical complexity at the nanoscale, enabling the analysis of biochemical heterogeneity in mammalian cancer cells on the scale of subcellular features.
Type of Material
Journal Article
Publisher
Wiley
Journal
Journal of Biophotonics
Volume
8
Issue
1-2
Start Page
133
End Page
141
Copyright (Published Version)
2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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