Flow-Enhanced Nonlinear Magnetophoresis for High-Resolution Bioseparation

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Title: Flow-Enhanced Nonlinear Magnetophoresis for High-Resolution Bioseparation
Authors: Li, Peng
Mahmood, Aamer
Lee, Gil U.
Permanent link: http://hdl.handle.net/10197/8377
Date: 20-Apr-2011
Abstract: A new mode of transport is described that was capable of high-resolution separation of superparamagnetic materials from complex mixtures based on their size. Laminar flow and a rotating external magnetic field were applied to superparamagnetic beads assembled on a semiperiodic micromagnet array. Beads at the edge of the micromagnet array oscillated in-phase with the external magnetic field with an amplitude that decreased with increasing frequency, omega, until they reached an immobilization frequency, omega(nu) where the beads stopped moving. Laminar flow along the edge of the array could be tuned to sweep the beads for which omega omega(i) undisturbed. Flow-enhanced nonlinear magnetophoresis (F-NLM) promises to enable multiple superparamagnetc bead types to be used in the fractionation of cells and implementation of diagnostic assays.
Funding Details: Irish Research Council for Science, Engineering and Technology
Science Foundation Ireland
Type of material: Journal Article
Publisher: American Chemical Society
Copyright (published version): 2011 American Chemical Society
Keywords: Monoclonal-antibodies;Bone-marrow;Cells;Microspheres;Separations;Mixtures;Magnetic separation;Magnetophoresis;Superparamagnetic beads;Micro-magnet arrays;Diagnostic assays;Cell separation;Lab-on-a-chip
DOI: 10.1021/la105126n
Language: en
Status of Item: Peer reviewed
Appears in Collections:Medicine Research Collection

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