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Flow-Enhanced Nonlinear Magnetophoresis for High-Resolution Bioseparation
Alternative Title
Flow enhanced non-linear magnetophoresis for high-resolution chip based bioseparation
Author(s)
Date Issued
2011-04-20
Date Available
2017-02-28T12:08:50Z
Abstract
A new mode of transport is described that was capable of high-resolution separation of superparamagnetic materials from complex mixtures based on their size. Laminar flow and a rotating external magnetic field were applied to superparamagnetic beads assembled on a semiperiodic micromagnet array. Beads at the edge of the micromagnet array oscillated in-phase with the external magnetic field with an amplitude that decreased with increasing frequency, omega, until they reached an immobilization frequency, omega(nu) where the beads stopped moving. Laminar flow along the edge of the array could be tuned to sweep the beads for which omega omega(i) undisturbed. Flow-enhanced nonlinear magnetophoresis (F-NLM) promises to enable multiple superparamagnetc bead types to be used in the fractionation of cells and implementation of diagnostic assays.
Sponsorship
Irish Research Council for Science, Engineering and Technology
Science Foundation Ireland
Type of Material
Journal Article
Publisher
American Chemical Society
Journal
Langmuir
Volume
27
Issue
10
Start Page
6496
End Page
6503
Copyright (Published Version)
2011 American Chemical Society
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
File(s)
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Name
revised_manuscript_for_Langmuir_14-03-2011.pdf
Size
1.75 MB
Format
Owning collection
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15
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