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Resistive pulse sensing of magnetic beads and supraparticle structures using tunable pores

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Download Biomicrofluidics_2012.pdf4.39 MB
Author(s)
Willmott, Geoff 
Platt, Mark 
Lee, Gil U. 
Uri
http://hdl.handle.net/10197/8384
Date Issued
2012
Date Available
02T16:48:39Z March 2017
Abstract
Tunable pores (TPs) have been used for resistive pulse sensing of 1 μm superparamagnetic beads, both dispersed and within a magnetic field. Upon application of this field, magnetic supraparticle structures (SPSs) were observed. Onset of aggregation was most effectively indicated by an increase in the mean event magnitude, with data collected using an automated thresholding method. Simulations enabled discrimination between resistive pulses caused by dimers and individual particles. Distinct but time-correlated peaks were often observed, suggesting that SPSs became separated in pressure-driven flow focused at the pore constriction. The distinct properties of magnetophoretic and pressure-driven transport mechanisms can explain variations in the event rate when particles move through an asymmetric pore in either direction, with or without a magnetic field applied. Use of TPs for resistive pulse sensing holds potential for efficient, versatile analysis and measurement of nano- and microparticles, while magnetic beads and particle aggregation play important roles in many prospective biosensing applications.
Other Sponsorship
The Royal Society of New Zealand’s International Mobility Fund
New Zealand’s Ministry for Science and Innovation
IEF Marie Curie fellowship Grant
Type of Material
Journal Article
Publisher
AIP Publishing
Journal
Biomicrofluidics
Volume
6
Issue
1
Copyright (Published Version)
2012 American Institute of Physics
Keywords
  • Magnetic fields

  • Aggregation

  • Bioelectrochemistry

  • Cluster analysis

  • Magnets

DOI
10.1063/1.3673596
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Owning collection
Medicine Research Collection
Scopus© citations
32
Acquisition Date
Jan 30, 2023
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