Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms

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Title: Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms
Authors: Reid, Helen M.
Kinsella, B. Therese
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Date: Sep-2015
Abstract: The prostanoid Prostacyclin plays diverse physiologic roles within the vasculature and other systems, and is widely implicated in several cardiovascular, pulmonary and renal diseases. Despite this, knowledge of the factors regulating expression of the I prostanoid receptor (the IP) remained largely unknown. This review details recent advances in understanding the key transcriptional regulators determining expression of the PTGIR gene in the human vasculature and the identification of novel interacting partners of the IP that impact on its function therein. Included in this are the trans-acting factors that regulate expression of the PTGIR under basal- and regulated-conditions, particularly those determining its up-regulation in response to cellular differentiation, estrogen and low serum-cholesterol. Moreover, the functional implications of the interactions between the IP with PDZK1, a multi PDZ-domain containing protein essential for reverse-cholesterol transport and endothelialization, and the IP with IKEPP, the intestinal and kidney enriched PDZ protein, for the role of the prostacyclin-IP axis within the vasculature are reviewed.
Funding Details: European Commission - European Regional Development Fund
Health Research Board
Irish Cancer Society
Science Foundation Ireland
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2015 Elsevier
Keywords: Prostacyclin receptor;Estrogen receptor;Sterol response element binding protein (SREBP);PDZK1(PDZ-domain-containing protein 1);IKEPP (intestinal and kidney enriched PDZ protein);C/EBP;CCAAT/enhancer binding protein;Rab11, gene;Cardiovascular
DOI: 10.1016/j.prostaglandins.2015.04.008
Language: en
Status of Item: Peer reviewed
Conference Details: 5th European Workshop on Lipid Mediators, Istanbul, Turkey, 23-24 October 2014
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection

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