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Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms
Author(s)
Date Issued
2015-09
Date Available
2017-04-07T15:34:07Z
Abstract
The prostanoid Prostacyclin plays diverse physiologic roles within the vasculature and other systems, and is widely implicated in several cardiovascular, pulmonary and renal diseases. Despite this, knowledge of the factors regulating expression of the I prostanoid receptor (the IP) remained largely unknown. This review details recent advances in understanding the key transcriptional regulators determining expression of the PTGIR gene in the human vasculature and the identification of novel interacting partners of the IP that impact on its function therein. Included in this are the trans-acting factors that regulate expression of the PTGIR under basal- and regulated-conditions, particularly those determining its up-regulation in response to cellular differentiation, estrogen and low serum-cholesterol. Moreover, the functional implications of the interactions between the IP with PDZK1, a multi PDZ-domain containing protein essential for reverse-cholesterol transport and endothelialization, and the IP with IKEPP, the intestinal and kidney enriched PDZ protein, for the role of the prostacyclin-IP axis within the vasculature are reviewed.
Sponsorship
European Commission - European Regional Development Fund
Health Research Board
Irish Cancer Society
Science Foundation Ireland
Other Sponsorship
Programme for Research in Third Level Institutes (PRTLI) 5
MolCellBiol programme
Wellcome Trust
Type of Material
Journal Article
Publisher
Elsevier
Journal
Prostaglandins and Other Lipid Mediators
Volume
121
Issue
Part A
Start Page
70
End Page
82
Copyright (Published Version)
2015 Elsevier
Language
English
Status of Item
Peer reviewed
Conference Details
5th European Workshop on Lipid Mediators, Istanbul, Turkey, 23-24 October 2014
This item is made available under a Creative Commons License
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Reid&Kinsella Prostacyclin Review 2015 POLM v121p70-82.pdf
Description
Main article (complete with figures)
Size
2.23 MB
Format
Owning collection
Scopus© citations
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