The Identification of a 1916 Irish Rebel: New Approach for Estimating Relatedness from Low Coverage Homozygous Genomes

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Title: The Identification of a 1916 Irish Rebel: New Approach for Estimating Relatedness from Low Coverage Homozygous Genomes
Authors: Fernandes, Daniel
Sirak, Kendra
Novak, Mario
Finarelli, John A.
Carlsson, Jeanette E. L.
Ferretti, Edmondo
Pinhasi, Ron
Carlsson, Jens
et al.
Permanent link: http://hdl.handle.net/10197/8434
Date: 30-Jan-2017
Abstract: Thomas Kent was an Irish rebel who was executed by British forces in the aftermath of the Easter Rising armed insurrection of 1916 and buried in a shallow grave on Cork prison’s grounds. In 2015, ninety-nine years after his death, a state funeral was offered to his living family to honor his role in the struggle for Irish independence. However, inaccuracies in record keeping did not allow the bodily remains that supposedly belonged to Kent to be identified with absolute certainty. Using a novel approach based on homozygous single nucleotide polymorphisms, we identified these remains to be those of Kent by comparing his genetic data to that of two known living relatives. As the DNA degradation found on Kent’s DNA, characteristic of ancient DNA, rendered traditional methods of relatedness estimation unusable, we forced all loci homozygous, in a process we refer to as 'forced homozygote approach'. The results were confirmed using simulated data for different relatedness classes. We argue that this method provides a necessary alternative for relatedness estimations, not only in forensic analysis, but also in ancient DNA studies, where reduced amounts of genetic information can limit the application of traditional methods.
Funding Details: European Research Council
Irish Research Council
Type of material: Journal Article
Publisher: Nature Publishing Group
Copyright (published version): 2017 the Authors
Keywords: Computational biology;Bioinformatics;Genomics
DOI: 10.1038/srep41529
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biology & Environmental Science Research Collection
Earth Institute Research Collection
Archaeology Research Collection

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