Bio-Nano-Magnetic Materials for Localized Mechanochemical Stimulation of Cell Growth and Death

Title: Bio-Nano-Magnetic Materials for Localized Mechanochemical Stimulation of Cell Growth and Death
Authors: Kilinc, Devrim
Dennis, Cindi L.
Lee, Gil U.
Permanent link: http://hdl.handle.net/10197/8460
Date: 20-Jul-2016
Abstract: Magnetic nanoparticles are promising new tools for therapeutic applications, such as magnetic nanoparticle hyperthermia therapy and targeted drug delivery. Recent in vitro studies have demonstrated that a force application with magnetic tweezers can also affect cell fate, suggesting a therapeutic potential for magnetically modulated mechanical stimulation. The magnetic properties of nanoparticles that induce physical responses and the subtle responses that result from mechanically induced membrane damage and/or intracellular signaling are evaluated. Magnetic particles with various physical, geometric, and magnetic properties and specific functionalization can now be used to apply mechanical force to specific regions of cells, which permit the modulation of cellular behavior through the use of spatially and time controlled magnetic fields. On one hand, mechanochemical stimulation has been used to direct the outgrowth on neuronal growth cones, indicating a therapeutic potential for neural repair. On the other hand, it has been used to kill cancer cells that preferentially express specific receptors. Advances made in the synthesis and characterization of magnetic nanomaterials and a better understanding of cellular mechanotransduction mechanisms may support the translation of mechanochemical stimulation into the clinic as an emerging therapeutic approach.
Funding Details: European Commission - European Regional Development Fund
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Copyright (published version): 2016 Wiley
Keywords: Cancer therapy;Magnetic nanoparticles;Magnetic tweezers;Mechanotransduction;Nanorods
DOI: 10.1002/adma.201504845
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection
Chemistry Research Collection

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