Charge and topography patterned lithium niobate provides physical cues to fluidically isolated cortical axons

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Title: Charge and topography patterned lithium niobate provides physical cues to fluidically isolated cortical axons
Authors: Kilinc, Devrim
Blasiak, Agata
Baghban, M. A.
Carville, N. Craig
Al-Aladi, A.
Al-Shammari, R. M.
Rice, James H.
Lee, Gil U.
Rodriguez, Brian J.
et al.
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Date: Jan-2017
Abstract: In vitro devices that combine chemotactic and physical cues are needed for understanding how cells integrate different stimuli. We explored the suitability of lithium niobate (LiNbO3), a transparent ferroelectric material that can be patterned with electrical charge domains and micro/nanotopography, as a neural substrate. On flat LiNbO3 z-surfaces with periodically alternating charge domains, cortical axons are partially aligned with domain boundaries. On submicron-deep etched trenches, neurites are aligned with the edges of the topographical features. Finally, we bonded a bicompartmental microfluidic chip to LiNbO3 surfaces patterned by etching, to create isolated axon microenvironments with predefined topographical cues. LiNbO3 is shown to be an emerging neuron culture substrate with tunable electrical and topographical properties that can be integrated with microfluidic devices, suitable for studying axon growth and guidance mechanisms under combined topographical/chemical stimuli.
Funding Details: European Commission - European Regional Development Fund
Higher Education Authority
Science Foundation Ireland
University College Dublin
Type of material: Journal Article
Publisher: AIP Publishing
Journal: Applied Physics Letters
Volume: 110
Copyright (published version): 2017 the Authors
Keywords: NanotechnologyNeruoscienceAxonal growth
DOI: 10.1063/1.4975304
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Physics Research Collection
Chemistry Research Collection

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