Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example

Files in This Item:
File Description SizeFormat 
Proline_Betaine_MNF_Comments_May_UNmarked-FINAL_pdf.pdf526.85 kBAdobe PDFDownload
Title: Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example
Authors: Gibbons, Helena
Michielsen, Charlotte J. R.
Rundle, Milena
McNulty, Breige A.
Nugent, Anne P.
Gibney, Michael J.
Brennan, Lorraine
et al.
Permanent link: http://hdl.handle.net/10197/8524
Date: 2017
Abstract: Scope: There is a dearth of studies demonstrating the use of dietary biomarkers for determination of food intake. The objective of this study was to develop calibration curves for use in quantifying citrus intakes in an independent cohort. Methods and results: Participants (n=50) from the NutriTech food-intake study consumed standardized breakfasts for three consecutive days over three consecutive weeks. Orange juice intake decreased over the weeks. Urine samples were analyzed by NMR-spectroscopy and proline betaine was quantified and normalized to osmolality. Calibration curves were developed and used to predict citrus intake in an independent cohort; the Irish National Adult Nutrition Survey (NANS) (n=565). Proline betaine displayed a dose-response relationship to orange juice intake in 24h and fasting samples (p<0.001). In a test set, predicted orange juice intakes displayed excellent agreement with true intake. There were significant associations between predicted intake measured in 24h and fasting samples and true intake(r=0.710- 0.919). Citrus intakes predicted for the NANS cohort demonstrated good agreement with self-reported intake and this agreement improved following normalization to osmolality. Conclusion: The developed calibration curves successfully predicted citrus intakes in an independent cohort. Expansion of this approach to other foods will be important for the development of objective intake measurements.
Funding Details: Department of Agriculture, Food and the Marine
European Research Council
Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Copyright (published version): 2017 Wiley
Keywords: Citrus fruit;Dietary assessment;Dose-response;Metabolomics;Proline betaine
DOI: 10.1002/mnfr.201700037
Language: en
Status of Item: Peer reviewed
Appears in Collections:Institute of Food and Health Research Collection
Agriculture and Food Science Research Collection

Show full item record

SCOPUSTM   
Citations 50

4
Last Week
1
Last month
checked on Jun 23, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.