Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example

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Title: Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example
Authors: Gibbons, HelenaMichielsen, Charlotte J. R.Rundle, MilenaMcNulty, Breige A.Nugent, Anne P.Gibney, Michael J.Brennan, Lorraineet al.
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Date: 2017
Online since: 2018-04-24T01:00:13Z
Abstract: Scope: There is a dearth of studies demonstrating the use of dietary biomarkers for determination of food intake. The objective of this study was to develop calibration curves for use in quantifying citrus intakes in an independent cohort. Methods and results: Participants (n=50) from the NutriTech food-intake study consumed standardized breakfasts for three consecutive days over three consecutive weeks. Orange juice intake decreased over the weeks. Urine samples were analyzed by NMR-spectroscopy and proline betaine was quantified and normalized to osmolality. Calibration curves were developed and used to predict citrus intake in an independent cohort; the Irish National Adult Nutrition Survey (NANS) (n=565). Proline betaine displayed a dose-response relationship to orange juice intake in 24h and fasting samples (p<0.001). In a test set, predicted orange juice intakes displayed excellent agreement with true intake. There were significant associations between predicted intake measured in 24h and fasting samples and true intake(r=0.710- 0.919). Citrus intakes predicted for the NANS cohort demonstrated good agreement with self-reported intake and this agreement improved following normalization to osmolality. Conclusion: The developed calibration curves successfully predicted citrus intakes in an independent cohort. Expansion of this approach to other foods will be important for the development of objective intake measurements.
Funding Details: Department of Agriculture, Food and the Marine
European Research Council
Health Research Board
Science Foundation Ireland
metadata.dc.description.othersponsorship: NutriTech
Type of material: Journal Article
Publisher: Wiley
Journal: Molecular Nutrition and Food Research
Volume: 61
Issue: 10
Copyright (published version): 2017 Wiley
Keywords: Citrus fruitDietary assessmentDose-responseMetabolomicsProline betaine
DOI: 10.1002/mnfr.201700037
Language: en
Status of Item: Peer reviewed
Appears in Collections:Institute of Food and Health Research Collection
Agriculture and Food Science Research Collection

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