Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: data from the European Food4Me Study

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Title: Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: data from the European Food4Me Study
Authors: Albani, Viviana
Celis-Morales, Carlos
O'Donovan, Clare
Walsh, Marianne C.
Woolhead, Clara
Forster, Hannah
Fallaize, Rosalind
Gibney, Michael J.
Gibney, Eileen R.
Brennan, Lorraine
et al.
Permanent link: http://hdl.handle.net/10197/8737
Date: Oct-2017
Abstract: ScopePrevious work highlighted the potential of odd-chain length saturated fatty acids as potential markers of dairy intake. The aim of this study was to assess the reproducibility of these biomarkers and their sensitivity to changes in dairy intake.Methods and ResultsFatty acid profiles and dietary intakes from food frequency questionnaires (FFQs) were measured three times over six months in the Food4Me Study. Reproducibility was explored through intra-class correlation coefficients (ICCs) and within-subject coefficients of variation (WCV). Sensitivity to changes in diet was examined using regression analysis. C15:0 blood levels showed high correlation over time (ICC: 0.62, 95% CI: 0.57, 0.68), however, the ICC for C17:0 was much lower (ICC: 0.32, 95% CI: 0.28, 0.46). The WCV for C15:0 was 16.6% and that for C17:0 was 14.6%. There were significant associations between changes in intakes of total dairy, high-fat dairy, cheese and butter and C15:0; and change in intakes of high-fat dairy and cream and C17:0.ConclusionsResults provide evidence of reproducibility of C15:0 levels over time and sensitivity to change in intake of high-fat dairy products with results comparable to the well-established biomarker of fish intake (EPA+DHA).
Funding Details: European Commission - Seventh Framework Programme (FP7)
Type of material: Journal Article
Publisher: Wiley
Copyright (published version): 2017 Wiley
Keywords: Dairy intake;Biomarkers;Pentadecanoic acid;Heptadecanoic acid;Intra-class correlation;Dried blood spots
DOI: 10.1002/mnfr.201700142
Language: en
Status of Item: Peer reviewed
Appears in Collections:Agriculture and Food Science Research Collection

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