Regimes of Biomolecular Ultrasmall Nanoparticle Interactions

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Title: Regimes of Biomolecular Ultrasmall Nanoparticle Interactions
Authors: Boselli, Luca
Polo, Ester
Castagnola, Valentina
Dawson, Kenneth A.
Permanent link: http://hdl.handle.net/10197/9070
Date: 3-Apr-2017
Abstract: Ultrasmall nanoparticles (USNPs), usually defined as NPs with core in the size range 1–3 nm, are a class of nanomaterials which show unique physicochemical properties, often different from larger NPs of the same material. Moreover, there are also indications that USNPs might have distinct properties in their biological interactions. For example, recent in vivo experiments suggest that some USNPs escape the liver, spleen, and kidney, in contrast to larger NPs that are strongly accumulated in the liver. Here, we present a simple approach to study the biomolecular interactions at the USNPs bio-nanointerface, opening up the possibility to systematically link these observations to microscopic molecular principles.
Funding Details: European Commission Horizon 2020
Irish Research Council
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Copyright (published version): 2017 the Authors
Keywords: Bioinorganic chemistry;Electrophoresis;Nanoparticles;Proteins;Proteomics
DOI: 10.1002/anie.201700343
Language: en
Status of Item: Peer reviewed
Appears in Collections:Centre for Bionano Interactions (CBNI) Research Collection
Chemistry Research Collection

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