Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device

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Title: Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device
Authors: Nguyen, Lan K.
Matallanas, David
Romano, David
Kholodenko, Boris N.
Kolch, Walter
Permanent link: http://hdl.handle.net/10197/9116
Date: 15-Jan-2015
Abstract: How do biochemical signaling pathways generate biological specificity? This question is fundamental to modern biology, and its enigma has been accentuated by the discovery that most proteins in signaling networks serve multifunctional roles. An answer to this question may lie in analyzing network properties rather than individual traits of proteins in order to elucidate design principles of biochemical networks that enable biological decision-making. We discuss how this is achieved in the MST2/Hippo-Raf-1 signaling network with the help of mathematical modeling and model-based analysis, which showed that competing protein interactions with affinities controlled by dynamic protein modifications can function as Boolean computing devices that determine cell fate decisions. In addition, we discuss areas of interest for future research and highlight how systems approaches would be of benefit
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: Taylor & Francis
Copyright (published version): 2015 the Authors
Keywords: Affinity mediated phosphorylation;Apoptosis;Cell fate decision;Competing protein interaction;Mathematical modelling;Proliferation;Signaling switches;Systems analysis
DOI: 10.4161/15384101.2014.973743
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection
Medicine Research Collection

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