Hypoxia-dependent regulation of inflammatory pathways in immune cells

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Title: Hypoxia-dependent regulation of inflammatory pathways in immune cells
Authors: Taylor, Cormac T.
Doherty, Glen
Fallon, Padraic G. (Padraic Gerard)
Cummins, Eoin P.
Permanent link: http://hdl.handle.net/10197/9139
Date: 25-Jul-2016
Online since: 2018-01-04T12:15:35Z
Abstract: Uncontrolled inflammation underpins a diverse range of diseases where effective therapy remains an unmet clinical need. Hypoxia is a prominent feature of the inflammatory microenvironment that regulates key transcription factors including HIF and NF-κB in both innate and adaptive immune cells. In turn, altered activity of the pathways controlled by these factors can affect the course of inflammation through the regulation of immune cell development and function. In this review, we will discuss these pathways and the oxygen sensors that confer hypoxic sensitivity in immune cells. Furthermore, we will describe how hypoxia-dependent pathways contribute to immunity and discuss their potential as therapeutic targets in inflammatory and infectious disease.
Funding Details: European Commission
Science Foundation Ireland
Type of material: Journal Article
Publisher: American Society for Clinical Investigation
Journal: Journal of Clinical Investigation
Volume: 126
Issue: 10
Start page: 3716
End page: 3724
Copyright (published version): 2016 American Society for Clinical Investigation
Keywords: Immune pathwaysImmune cellsHypoxia-dependent regulationsNF-kBHIFHypoxic sensitivityNetwork biology
DOI: 10.1172/JCI84433
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection
Medicine Research Collection

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