Hypoxia-dependent regulation of inflammatory pathways in immune cells

Files in This Item:
File Description SizeFormat 
PUB Vers. Hypoxia-dependent regulation of inflammatory pathways in Immune Cells.pdf1.13 MBAdobe PDFDownload
Title: Hypoxia-dependent regulation of inflammatory pathways in immune cells
Authors: Taylor, Cormac T.
Doherty, Glen
Fallon, Padraic G. (Padraic Gerard)
Cummins, Eoin P.
Permanent link: http://hdl.handle.net/10197/9139
Date: 25-Jul-2016
Abstract: Uncontrolled inflammation underpins a diverse range of diseases where effective therapy remains an unmet clinical need. Hypoxia is a prominent feature of the inflammatory microenvironment that regulates key transcription factors including HIF and NF-κB in both innate and adaptive immune cells. In turn, altered activity of the pathways controlled by these factors can affect the course of inflammation through the regulation of immune cell development and function. In this review, we will discuss these pathways and the oxygen sensors that confer hypoxic sensitivity in immune cells. Furthermore, we will describe how hypoxia-dependent pathways contribute to immunity and discuss their potential as therapeutic targets in inflammatory and infectious disease.
Funding Details: European Commission
Science Foundation Ireland
Type of material: Journal Article
Publisher: American Society for Clinical Investigation
Copyright (published version): 2016 American Society for Clinical Investigation
Keywords: Immune pathways;Immune cells;Hypoxia-dependent regulations;NF-kB;HIF;Hypoxic sensitivity;Network biology
DOI: 10.1172/JCI84433
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection
Medicine Research Collection

Show full item record

SCOPUSTM   
Citations 20

12
Last Week
0
Last month
checked on Jun 23, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.