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Hypoxia-dependent regulation of inflammatory pathways in immune cells
Date Issued
2016-07-25
Date Available
2018-01-04T12:15:35Z
Abstract
Uncontrolled inflammation underpins a diverse range of diseases where effective therapy remains an unmet clinical need. Hypoxia is a prominent feature of the inflammatory microenvironment that regulates key transcription factors including HIF and NF-κB in both innate and adaptive immune cells. In turn, altered activity of the pathways controlled by these factors can affect the course of inflammation through the regulation of immune cell development and function. In this review, we will discuss these pathways and the oxygen sensors that confer hypoxic sensitivity in immune cells. Furthermore, we will describe how hypoxia-dependent pathways contribute to immunity and discuss their potential as therapeutic targets in inflammatory and infectious disease.
Sponsorship
European Commission
Science Foundation Ireland
Other Sponsorship
European Union
Type of Material
Journal Article
Publisher
American Society for Clinical Investigation
Journal
Journal of Clinical Investigation
Volume
126
Issue
10
Start Page
3716
End Page
3724
Copyright (Published Version)
2016 American Society for Clinical Investigation
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Format
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