Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

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Title: Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort
Authors: O'Gorman, AoifeSuvitaival, T.Ahonen, L.Roche, Helen M.Brennan, Lorraineet al.
Permanent link: http://hdl.handle.net/10197/9152
Date: 26-Sep-2017
Online since: 2018-01-10T12:15:30Z
Abstract: The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and lipidomic approaches in combination with multivariate statistical analysis were applied to identify plasma alterations in children (age 11) (38 cases vs 67 controls) and adolescents (age 18) (36 cases vs 117 controls) preceeding or coincident with the development of psychotic disorder (PD) at age 18 in the Avon Longitudinal Study of Parents and Children (ALSPAC). Overall, 179 lipids were identified at age 11, with 32 found to be significantly altered between the control and PD groups. Following correction for multiple comparisons, 8 of these lipids remained significant (lysophosphatidlycholines (LPCs) LPC(18:1), LPC(18:2), LPC(20:3); phosphatidlycholines (PCs) PC(32:2; PC(34:2), PC(36:4), PC(0-34-3) and sphingomyelin (SM) SM(d18:1/24:0)), all of which were elevated in the PD group. At age 18, 23 lipids were significantly different between the control and PD groups, although none remained significant following correction for multiple comparisons. In conclusion, the findings indicate that the lipidome is altered in the blood during childhood, long before the development of psychotic disorder. LPCs in particular are elevated in those who develop PD, indicating inflammatory abnormalities and altered phospholipid metabolism. These findings were not found at age 18, suggesting there may be ongoing alterations in the pathophysiological processes from prodrome to onset of PD.
Funding Details: European Research Council
Health Research Board
Wellcome Trust
Funding Details: UK Medical Council
Type of material: Journal Article
Publisher: Springer Nature
Journal: Translational Psychiatry
Volume: 7
Issue: e1240
Copyright (published version): 2017 the Authors
Keywords: Psychotic disorderSchizophreniaMetabolomicsLipidomicsBiomarkers
DOI: 10.1038/tp.2017.211
Language: en
Status of Item: Peer reviewed
ISSN: 2158-3188
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Conway Institute Research Collection
Institute of Food and Health Research Collection
Public Health, Physiotherapy and Sports Science Research Collection
Agriculture and Food Science Research Collection

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