Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

Files in This Item:
File Description SizeFormat 
Identification_of_a_plasma_signature_of_psychotic_.pdf350.39 kBAdobe PDFDownload
Title: Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort
Authors: O'Gorman, Aoife
Suvitaival, T.
Ahonen, L.
Roche, Helen M.
Brennan, Lorraine
et al.
Permanent link: http://hdl.handle.net/10197/9152
Date: 26-Sep-2017
Abstract: The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and lipidomic approaches in combination with multivariate statistical analysis were applied to identify plasma alterations in children (age 11) (38 cases vs 67 controls) and adolescents (age 18) (36 cases vs 117 controls) preceeding or coincident with the development of psychotic disorder (PD) at age 18 in the Avon Longitudinal Study of Parents and Children (ALSPAC). Overall, 179 lipids were identified at age 11, with 32 found to be significantly altered between the control and PD groups. Following correction for multiple comparisons, 8 of these lipids remained significant (lysophosphatidlycholines (LPCs) LPC(18:1), LPC(18:2), LPC(20:3); phosphatidlycholines (PCs) PC(32:2; PC(34:2), PC(36:4), PC(0-34-3) and sphingomyelin (SM) SM(d18:1/24:0)), all of which were elevated in the PD group. At age 18, 23 lipids were significantly different between the control and PD groups, although none remained significant following correction for multiple comparisons. In conclusion, the findings indicate that the lipidome is altered in the blood during childhood, long before the development of psychotic disorder. LPCs in particular are elevated in those who develop PD, indicating inflammatory abnormalities and altered phospholipid metabolism. These findings were not found at age 18, suggesting there may be ongoing alterations in the pathophysiological processes from prodrome to onset of PD.
Funding Details: European Research Council
Health Research Board
Wellcome Trust
Type of material: Journal Article
Publisher: Springer Nature
Journal: Translational Psychiatry
Volume: 7
Issue: e1240
Copyright (published version): 2017 the Authors
Keywords: Psychotic disorderSchizophreniaMetabolomicsLipidomicsBiomarkers
DOI: 10.1038/tp.2017.211
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Institute of Food and Health Research Collection
Public Health, Physiotherapy and Sports Science Research Collection
Agriculture and Food Science Research Collection

Show full item record

SCOPUSTM   
Citations 50

4
Last Week
1
Last month
checked on Sep 18, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.