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Proteome-wide association studies identify biochemical modules associated with a wing size phenotype in Drosophila melanogaster
Editor(s)
Date Issued
2016-09-01
Date Available
2018-01-24T12:37:46Z
Abstract
The manner by which genetic diversity within a population generates individual phenotypes is a fundamental question of biology. To advance the understanding of the genotype–phenotype relationships towards the level of biochemical processes, we perform a proteome-wide association study (PWAS) of a complex quantitative phenotype. We quantify the variation of wing imaginal disc proteomes in Drosophila genetic reference panel (DGRP) lines using SWATH mass spectrometry. In spite of the very large genetic variation (1/36 bp) between the lines, proteome variability is surprisingly small, indicating strong molecular resilience of protein expression patterns. Proteins associated with adult wing size form tight co-variation clusters that are enriched in fundamental biochemical processes. Wing size correlates with some basic metabolic functions, positively with glucose metabolism but negatively with mitochondrial respiration and not with ribosome biogenesis. Our study highlights the power of PWAS to filter functional variants from the large genetic variability in natural populations.
Sponsorship
European Research Council
Other Sponsorship
SystemsX.ch
Swiss National Science Foundation
Type of Material
Journal Article
Publisher
Springer Nature
Journal
Nature Communications
Volume
7
Copyright (Published Version)
2016 the Authors
Keywords
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Proteome-wide association studies identify biochemical modules A Ebhdart 10.1038 ncomms12649.pdf
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2.25 MB
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