Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles
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|Title:||Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles||Authors:||Morales, Javier O.
Brayden, David James
|Permanent link:||http://hdl.handle.net/10197/9307||Date:||Oct-2017||Abstract:||Buccal delivery of macromolecules (biologics) sets a great challenge for researchers. Although several niche small molecule products have been approved as simple sprays, tablets and oral films, it is not simply a case of adapting existing technologies to biologics. Buccal delivery of insulin has reached clinical trials with two approaches: oromucosal sprays of the peptide with permeation enhancers, and embedded gold nanoparticles in a dissolvable film. However, neither of these approaches have led to FDA approvals likely due to poor efficacy, submaximal peptide loading in the dosage form, and to wide intra-subject variability in pharmacokinetics and pharmacodynamics. It is likely however that printed film designs with lower molecular weight stable biotech payloads including lipophilic glucagon-like 1 (GLP-1) agonists and macrocycles with long half-lives will generate greater efficacy than was achieved to date for insulin..||Funding Details:||Science Foundation Ireland||Type of material:||Journal Article||Publisher:||Elsevier||Journal:||Current Opinion in Pharmacology||Volume:||36||Start page:||22||End page:||28||Copyright (published version):||2017 Elsevier||Keywords:||Buccal drug delivery; Oral peptides; Non-injected drug delivery; Food effects on absorption||DOI:||10.1016/j.coph.2017.07.011||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Conway Institute Research Collection|
Veterinary Medicine Research Collection
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