Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles

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Title: Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles
Authors: Morales, Javier O.Brayden, David James
Permanent link: http://hdl.handle.net/10197/9307
Date: Oct-2017
Abstract: Buccal delivery of macromolecules (biologics) sets a great challenge for researchers. Although several niche small molecule products have been approved as simple sprays, tablets and oral films, it is not simply a case of adapting existing technologies to biologics. Buccal delivery of insulin has reached clinical trials with two approaches: oromucosal sprays of the peptide with permeation enhancers, and embedded gold nanoparticles in a dissolvable film. However, neither of these approaches have led to FDA approvals likely due to poor efficacy, submaximal peptide loading in the dosage form, and to wide intra-subject variability in pharmacokinetics and pharmacodynamics. It is likely however that printed film designs with lower molecular weight stable biotech payloads including lipophilic glucagon-like 1 (GLP-1) agonists and macrocycles with long half-lives will generate greater efficacy than was achieved to date for insulin..
Funding Details: Science Foundation Ireland
metadata.dc.description.othersponsorship: Fondo de Investigación Avanzado en Areas Prioritarias (FONDAP)
Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT)
Type of material: Journal Article
Publisher: Elsevier
Journal: Current Opinion in Pharmacology
Volume: 36
Start page: 22
End page: 28
Copyright (published version): 2017 Elsevier
Keywords: Buccal drug deliveryOral peptidesNon-injected drug deliveryFood effects on absorption
DOI: 10.1016/j.coph.2017.07.011
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Veterinary Medicine Research Collection

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