Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma

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Title: Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma
Authors: Slater, Kayleigh
Hoo, Pei Sian
Buckley, A. M.
Piulats, J. M.
Villanueva, A.
Portela, A.
Kennedy, Breandán
Permanent link: http://hdl.handle.net/10197/9533
Date: Sep-2018
Abstract: Uveal melanoma is a rare, but deadly, form of eye cancer that arises from melanocytes within the uveal tract. Although advances have emerged in treatment of the primary tumour, patients are still faced with vision loss, eye enucleation and lethal metastatic spread of the disease. Approximately 50% of uveal melanoma patients develop metastases, which occur most frequently in the liver. Metastatic patients encounter an extremely poor prognosis; as few as 8% survive beyond 2 years. Understanding of the genetic underpinnings of this fatal disease evolved in recent years with the identification of new oncogenic mutations that drive uveal melanoma pathogenesis. Despite this progress, the lack of successful therapies or a proven standard-of-care for uveal melanoma highlights the need for new targeted therapies. This review focuses on the recently identified CYSLTR2 oncogenic mutation in uveal melanoma. Here, we evaluate the current status of uveal melanoma and investigate how to better understand the role of this CYSLTR2 mutation in the disease and implications for patients harbouring this mutation.
Funding Details: European Commission Horizon 2020
European Commission - Seventh Framework Programme (FP7)
Irish Research Council
Type of material: Journal Article
Publisher: Springer
Journal: Cancer Metastasis Reviews
Volume: 37
Issue: 2-3
Start page: 335
End page: 345
Copyright (published version): 2018 Springer
Keywords: Cysteinyl leukotriene receptor 2Cysteinyl leukotriene signallingPatient-derived xenograft modelsUveal melanoma
DOI: 10.1007/s10555-018-9751-z
Language: en
Status of Item: Peer reviewed
metadata.dc.date.available: 2018-10-30T12:25:56Z
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection

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