Nanomechanics of Cells and Biomaterials Studied by Atomic Force Microscopy
Files in This Item:
|Kilpatrick et al Adv Healthcare Materials 2015.pdf||850.15 kB||Adobe PDF||Download|
|Title:||Nanomechanics of Cells and Biomaterials Studied by Atomic Force Microscopy||Authors:||Kilpatrick, J. I.
Rodriguez, Brian J.
|Permanent link:||http://hdl.handle.net/10197/9664||Date:||22-Jul-2015||Online since:||2019-03-25T08:49:12Z||Abstract:||The behavior and mechanical properties of cells are strongly dependent on the biochemical and biomechanical properties of their microenvironment. Thus, understanding the mechanical properties of cells, extracellular matrices, and biomaterials is key to understanding cell function and to develop new materials with tailored mechanical properties for tissue engineering and regenerative medicine applications. Atomic force microscopy (AFM) has emerged as an indispensable technique for measuring the mechanical properties of biomaterials and cells with high spatial resolution and force sensitivity within physiologically relevant environments and timescales in the kPa to GPa elastic modulus range. The growing interest in this field of bionanomechanics has been accompanied by an expanding array of models to describe the complexity of indentation of hierarchical biological samples. Furthermore, the integration of AFM with optical microscopy techniques has further opened the door to a wide range of mechanotransduction studies. In recent years, new multidimensional and multiharmonic AFM approaches for mapping mechanical properties have been developed, which allow the rapid determination of, for example, cell elasticity. This Progress Report provides an introduction and practical guide to making AFM-based nanomechanical measurements of cells and surfaces for tissue engineering applications. Atomic force microscopy is an indispensable tool for nanomechanical measurements of cells, cell microenvironments, and biomaterials. The mechanical properties of cells and their function are influenced by the elasticity of the extracellular matrix. Thus, understanding the nanomechanical properties is key for tissue engineering applications.||Funding Details:||European Commission - European Regional Development Fund
Science Foundation Ireland
|Type of material:||Journal Article||Publisher:||Wiley||Journal:||Advanced Healthcare Materials||Volume:||4||Issue:||16||Start page:||2456||End page:||2474||Copyright (published version):||2015 Wiley||Keywords:||Cell elasticity; Nanomechanics; Biomaterials; Atomic force microscopy; Tissue engineering; Cellular mechanotransduction; Nanotechnology||DOI:||10.1002/adhm.201500229||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Conway Institute Research Collection|
Physics Research Collection
Show full item record
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.