Poly(ethylene glycol)-based backbones with high peptide loading capacities

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Title: Poly(ethylene glycol)-based backbones with high peptide loading capacities
Authors: O'Connor, Aoife
Marsat, Jean-Noël
Mitrugno, Annachiara
Brayden, David James
et al.
Permanent link: http://hdl.handle.net/10197/9665
Date: 30-Oct-2014
Online since: 2019-03-25T09:20:29Z
Abstract: Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylene glycol)s are utilised for peptide conjugation, to increase their potential loading capacities. These poly(ethylene glycol) derivatives are conjugated to peptide sequences containing representative side-chain functionalised amino acids, using different conjugation chemistries, including copper-catalysed azide-alkyne cycloaddition, amide coupling and thiol-ene reactions. Conjugation of a sequence containing the RGD motif to poly(allyl glycidyl ether) by the thiol-ene reaction, provided a conjugate which could be used in platelet adhesion studies.
Funding Details: Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: MDPI
Journal: Molecules
Volume: 19
Issue: 11
Start page: 17559
End page: 17577
Copyright (published version): 2014 the Authors
Keywords: Blood plateletsAzidesPolyethylene glycolsEpoxy compoundsAlkynesSulfhydryl compoundsAmino acidsPeptide-polymer conjugatesLoading capacityPoly(allyl glycidyl ether)Thiol-ene conjugation
DOI: 10.3390/molecules191117559
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Veterinary Medicine Research Collection

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