The role of HIF in immunity and inflammation

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Title: The role of HIF in immunity and inflammation
Authors: Cummins, Eoin P.
Keogh, Ciara E.
Crean, Daniel
Taylor, Cormac T.
Permanent link: http://hdl.handle.net/10197/9767
Date: Mar-2016
Online since: 2019-04-02T08:48:50Z
Abstract: Uncontrolled or non-resolving inflammation underpins a range of disease states including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a prominent feature of chronically inflamed tissues. This is due to elevated oxygen consumption by highly metabolically active inflamed resident cells and activated infiltrating immunocytes, as well as diminished oxygen supply due to vascular dysfunction. Tissue hypoxia can have a significant impact upon inflammatory signaling pathways in immune and non-immune cells and this can impact upon disease progression. In this review, we will discuss the relationship between tissue hypoxia and inflammation and identify how hypoxia-sensitive signaling pathways are potential therapeutic targets in chronic inflammatory disease.
Type of material: Review
Publisher: Elsevier
Journal: Molecular Aspects of Medicine
Volume: 47-48
Start page: 24
End page: 34
Copyright (published version): 2015 Elsevier
Keywords: HypoxiaHypoxia inducible factorLeukocyteInflammation
DOI: 10.1016/j.mam.2015.12.004
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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