Crosstalk between toll-like receptors and hypoxia-dependent pathways in health and disease

Title: Crosstalk between toll-like receptors and hypoxia-dependent pathways in health and disease
Authors: Crifo, Bianca
Taylor, Cormac T.
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Date: Feb-2016
Online since: 2019-04-02T11:01:32Z
Abstract: Toll-like receptors (TLRs) play an important role in shaping the host immune response to infection and inflammation. Tissue hypoxia is a common microenvironmental feature of infected and inflamed tissues. Furthermore, hypoxia significantly impacts the development of immune and inflammatory responses through the regulation of host innate and adaptive immunity. Here, we will discuss current knowledge in relation to the crosstalk that exists between toll-like receptor- and hypoxia-dependent signaling pathways in health and disease.
Type of material: Journal Article
Publisher: BMJ
Journal: Journal of Investigative Medicine
Volume: 64
Issue: 2
Start page: 369
End page: 375
Copyright (published version): 2016 American Federation for Medical Research
Keywords: HIF-1HiF hydroxylasesHypoxiaInfectionToll-like receptors
DOI: 10.1097/JIM.0000000000000228
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection
Medicine Research Collection

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