Crosstalk between toll-like receptors and hypoxia-dependent pathways in health and disease
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|Title:||Crosstalk between toll-like receptors and hypoxia-dependent pathways in health and disease||Authors:||Crifo, Bianca
Taylor, Cormac T.
|Permanent link:||http://hdl.handle.net/10197/9768||Date:||Feb-2016||Online since:||2019-04-02T11:01:32Z||Abstract:||Toll-like receptors (TLRs) play an important role in shaping the host immune response to infection and inflammation. Tissue hypoxia is a common microenvironmental feature of infected and inflamed tissues. Furthermore, hypoxia significantly impacts the development of immune and inflammatory responses through the regulation of host innate and adaptive immunity. Here, we will discuss current knowledge in relation to the crosstalk that exists between toll-like receptor- and hypoxia-dependent signaling pathways in health and disease.||Type of material:||Journal Article||Publisher:||BMJ||Journal:||Journal of Investigative Medicine||Volume:||64||Issue:||2||Start page:||369||End page:||375||Copyright (published version):||2016 American Federation for Medical Research||Keywords:||HIF-1; HiF hydroxylases; Hypoxia; Infection; Toll-like receptors||DOI:||10.1097/JIM.0000000000000228||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Conway Institute Research Collection|
SBI Research Collection
Medicine Research Collection
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