The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells
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|Title:||The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells||Authors:||Fey, Dirk
Rukhlenko, Oleksii S.
Kholodenko, Boris N.
|Permanent link:||http://hdl.handle.net/10197/9769||Date:||Oct-2016||Online since:||2019-04-02T11:12:23Z||Abstract:||The intricate dynamic control and plasticity of RAS to ERK mitogenic, survival and apoptotic signalling has mystified researches for more than 30 years. Therapeutics targeting the oncogenic aberrations within this pathway often yield unsatisfactory, even undesired results, as in the case of paradoxical ERK activation in response to RAF inhibition. A direct approach of inhibiting single oncogenic proteins misses the dynamic network context governing the network signal processing. In this review, we discuss the signalling behaviour of RAS and RAF proteins in normal and in cancer cells, and the emerging systems-level properties of the RAS-to-ERK signalling network. We argue that to understand the dynamic complexities of this control system, mathematical models including mechanistic detail are required. Looking into the future, these dynamic models will build the foundation upon which more effective, rational approaches to cancer therapy will be developed.||Funding Details:||European Commission Horizon 2020
European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
|Type of material:||Review||Publisher:||Elsevier||Journal:||Seminars in Cell & Developmental Biology||Volume:||58||Start page:||96||End page:||107||Copyright (published version):||2016 Elsevier||Keywords:||Dynamic modelling; MAPK cascade; Systems biology||DOI:||10.1016/j.semcdb.2016.06.011||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Conway Institute Research Collection|
SBI Research Collection
Medicine Research Collection
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