The spatiotemporal regulation of RAS signalling

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Title: The spatiotemporal regulation of RAS signalling
Authors: Herrero, Ana
Matallanas, David
Kolch, Walter
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Date: 19-Oct-2016
Online since: 2019-04-02T11:19:24Z
Abstract: Nearly 30% of human tumours harbour mutations in RAS family members. Post-translational modifications and the localisation of RAS within subcellular compartments affect RAS interactions with regulator, effector and scaffolding proteins. New insights into the control of spatiotemporal RAS signalling reveal that activation kinetics and subcellular compartmentalisation are tightly coupled to the generation of specific biological outcomes. Computational modelling can help utilising these insights for the identification of new targets and design of new therapeutic approaches.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Type of material: Journal Article
Publisher: Portland Press
Journal: Biochemical Society Transactions
Volume: 44
Issue: 5
Start page: 1517
End page: 1522
Copyright (published version): 2016 the Authors
Keywords: RASCellular localisationSite-specific signalling
DOI: 10.1042/BST20160127
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection
Medicine Research Collection

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