Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration
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|Title:||Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration||Authors:||Santra, Tapesh
Kholodenko, Boris N.
|Permanent link:||http://hdl.handle.net/10197/9783||Date:||13-Feb-2014||Online since:||2019-04-03T09:01:31Z||Abstract:||The ever-increasing capacity of biological molecular data acquisition outpaces our ability to understand the meaningful relationships between molecules in a cell. Multiple databases were developed to store and organize these molecular data. However, emerging fundamental questions about concerted functions of these molecules in hierarchical cellular networks are poorly addressed. Here we review recent advances in the development of publically available databases that help us analyze the signal integration and processing by multilayered networks that specify biological responses in model organisms and human cells.||Funding Details:||European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
|Type of material:||Journal Article||Journal:||PLoS Computational Biology||Volume:||10||Issue:||2||Copyright (published version):||2014 the Authors||Keywords:||Eukaryotic signaling; Data integration; Protein interaction networks; Transcriptional control; Hierarchical cellular networks||DOI:||10.1371/journal.pcbi.1003385||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||SBI Research Collection|
Medicine Research Collection
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