Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration

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Title: Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration
Authors: Santra, Tapesh
Kolch, Walter
Kholodenko, Boris N.
Permanent link: http://hdl.handle.net/10197/9783
Date: 13-Feb-2014
Online since: 2019-04-03T09:01:31Z
Abstract: The ever-increasing capacity of biological molecular data acquisition outpaces our ability to understand the meaningful relationships between molecules in a cell. Multiple databases were developed to store and organize these molecular data. However, emerging fundamental questions about concerted functions of these molecules in hierarchical cellular networks are poorly addressed. Here we review recent advances in the development of publically available databases that help us analyze the signal integration and processing by multilayered networks that specify biological responses in model organisms and human cells.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of material: Journal Article
Journal: PLoS Computational Biology
Volume: 10
Issue: 2
Copyright (published version): 2014 the Authors
Keywords: Eukaryotic signalingData integrationProtein interaction networksTranscriptional controlHierarchical cellular networks
DOI: 10.1371/journal.pcbi.1003385
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection
Medicine Research Collection

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