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Nanostructured apatite-mullite glass-ceramics for enhanced primary human osteoblast cell response
Date Issued
2017-12-11
Date Available
2019-04-04T09:37:32Z
Abstract
This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca10(PO4)6F2) and bioinert mullite (Si2Al6O13) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched nanostructured glass-ceramic with the bioactive phase removed, and a borosilicate glass control. Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface compared to the smooth bioactive surface, while cell viability at both time points was significantly greater on both nanostructured and smooth bioactive surfaces compared to the control.
Sponsorship
Higher Education Authority
Type of Material
Journal Article
Publisher
Elsevier
Journal
Materials Letters
Volume
214
Start Page
268
End Page
271
Copyright (Published Version)
2017 Elsevier
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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